concept

RESVERATROL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RESVERATROL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

310Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

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💡 Concept Info

Name	RESVERATROL
Key Genes/Proteins	AKT, AMPK, AMYLOID, aplp1, APOE
Related Diseases	ACETYLCHOLINE, aging, ALZHEIMER, Alzheimer'S Disease, ALZHEIMER'S DISEASE
Related Pathways	AMPK PATHWAY

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Resveratrol and Sirtuin Activation for Neurodegeneration

therapeutic · 1841 words

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Pathway Diagram

graph TD
    RESVERATROL["RESVERATROL"]
    RESVERATROL -.protects against.-> UVA_Induced_Photoaging["UVA-Induced Photoaging"]
    RESVERATROL -->|"activates"| SIRT1["SIRT1"]
    RESVERATROL -->|"reduces_phosphorylation_of"| IRS1["IRS1"]
    RESVERATROL -->|"mediates"| AMPK_Phosphorylation["AMPK Phosphorylation"]
    RESVERATROL -->|"activates"| insulin_signaling["insulin signaling"]
    RESVERATROL -->|"inhibits"| Apoptosis["Apoptosis"]
    RESVERATROL -->|"inhibits"| Collagen_Fiber_Degradation["Collagen Fiber Degradation"]
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -.biomarker for.-> RESVERATROL
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| RESVERATROL
    FOXO1["FOXO1"] -->|"activates"| RESVERATROL
    FIBROBLASTS["FIBROBLASTS"] -->|"activates"| RESVERATROL
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| RESVERATROL
    CELL_CYCLE["CELL CYCLE"] -->|"activates"| RESVERATROL
    APOPTOSIS["APOPTOSIS"] -->|"activates"| RESVERATROL

Outgoing (200)

Target	Relation	Type	Str
UVA-Induced Photoaging	protects_against	disease	0.95
SIRT1	activates	protein	0.90
AMPK Phosphorylation	mediates	process	0.90
IRS1	reduces_phosphorylation_of	protein	0.90
Axonal Degeneration	protects_against	process	0.90
SIRT1-DBC1 Complex	modulates	mechanism	0.85
Collagen Fiber Degradation	inhibits	process	0.85
Apoptosis	inhibits	process	0.85
insulin signaling	activates	pathway	0.85
SIRT1	activates	protein	0.85
mitochondrial function	associated_with	phenotype	0.80
diet-induced obesity	protects_against	disease	0.80
Inflammatory Response	inhibits	process	0.80
AMPK	activates	protein	0.80
insulin resistance	protects_against	disease	0.80
TAU	modulates	protein	0.80
SIRT1	modulates	gene	0.80
AMPK	activates	protein	0.80
mitochondrial biogenesis	promotes	process	0.80
autophagy	modulates	process	0.80
Skin Fibroblasts	expressed_in	cell_type	0.75
ALZHEIMER'S DISEASE	treats	disease	0.75
NAD+ metabolism	modulates	pathway	0.75
AGING	modulates	process	0.75
gut microbiota dysbiosis	prevents	phenotype	0.75
CDK5	modulates	gene	0.75
Parkinson's disease	treats	disease	0.70
AMPK	targets	gene	0.70
AD	targets	disease	0.70
DNA	targets	gene	0.70
Alzheimer's disease	treats	disease	0.70
oxidative stress	regulates	process	0.70
Alzheimer's disease	protects_against	disease	0.70
miRNA	regulates	biological_process	0.70
inflammation	regulates	process	0.70
oxidative stress	protects_against	process	0.70
Oxidative Stress	protects_against	process	0.70
AMPK	regulates	protein	0.70
RELA	treats	gene	0.70
alcohol-induced neurodegeneration	protects_against	disease	0.70
MICROGLIA	targets	cell_type	0.65
INSULIN SIGNALING	treats	pathway	0.65
PYROPTOSIS	activates	phenotype	0.65
AUTOPHAGY	regulates	phenotype	0.65
AUTOPHAGY	treats	phenotype	0.65
MICROGLIA	inhibits	cell_type	0.65
ROS	phosphorylates	gene	0.65
TAU	phosphorylates	gene	0.65
SIRT3	inhibits	gene	0.65
SIRT3	activates	gene	0.65

Incoming (110)

Source	Relation	Type	Str
FERROPTOSIS	treats	phenotype	0.65
AMPK	phosphorylates	gene	0.65
NEURON	phosphorylates	cell_type	0.65
ENDOTHELIAL	targets	cell_type	0.65
ALZHEIMER	treats	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
PARKIN	treats	gene	0.65
RAGE	targets	gene	0.65
PI3K	targets	gene	0.65
AKT	targets	gene	0.65
PARKIN	expressed_in	gene	0.65
PARKINSON'S DISEASE	treats	disease	0.65
PARKINSON	treats	disease	0.65
PLP1	interacts_with	gene	0.65
MACROPHAGE	targets	cell_type	0.65
ALZHEIMER'S DISEASE	therapeutic_target	disease	0.50
CELL SURVIVAL	associated_with	concept	0.50
SOD2	activates	gene	0.50
MICRORNAS	associated_with	gene	0.50
INFLAMMATION	associated_with	phenotype	0.50
microglia	regulates	cell_type	0.50
Macrophage	regulates	cell_type	0.50
Endothelial Cell	regulates	cell_type	0.50
ENDOTHELIAL	regulates	concept	0.50
NEURODEGENERATION	associated_with	phenotype	0.50
PP2A	activates	gene	0.50
oxidative stress	activates	phenotype	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
Parkinson's Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
PARKINSON'S	associated_with	concept	0.50
ALZHEIMER	expressed_in	gene	0.50
PARKINSON	expressed_in	gene	0.50
Alzheimer'S Disease	expressed_in	disease	0.50
Parkinson's Disease	expressed_in	disease	0.50
disease	expressed_in	disease	0.50
ALZHEIMER'S	expressed_in	concept	0.50
PARKINSON'S	expressed_in	concept	0.50
GENE EXPRESSION	expressed_in	concept	0.50
Pi3K	associated_with	pathway	0.50
STAT3	associated_with	gene	0.50
RAGE	associated_with	gene	0.50
CASP3	associated_with	gene	0.50
PARKINSON'S DISEASE	biomarker_for	disease	0.50
ACETYLCHOLINE	associated_with	phenotype	0.50
TNFA	regulates	gene	0.50
C3AR1	regulates	gene	0.50
Nf-Kb	regulates	pathway	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Clinical Trial Landscaping for Alzheimer's Disease Therapeutics

neurodegeneration | 2026-04-16 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

What is the current clinical trial landscape for AD therapeutics, and which mech

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Is the amyloid concentration in AD clinical trials rational given lecanemab's ap

closed · Rounds: 4 · Score: 0.70 · 2026-04-16