gene

ERCC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERCC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

0Analyses

27Outgoing

12Incoming

0Experiments

0Debates

Summary

ERCC1 — Excision Repair Cross-Complementation Group 1

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🧬 Gene Info

Gene Symbol	ERCC1
Full Name	Excision Repair Cross-Complementation Group 1
Function	ERCC1 functions as part of a heterodimer with XPF (ERCC4) to perform the critical incision step in nucleotide excision repair:
Primary Expression	all brain regions
Pathways	Apoptosis
Ensembl ID	ENSG00000112020
GeneCards	ERCC1
Human Protein Atlas	ERCC1
Associated Diseases	Ms, Osteoporosis
Interactions	AGING, AND, APOPTOSIS, EFNB1, EXERCISE, P21
KG Connections	39 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ERCC1 — Excision Repair Cross-Complementation Group 1

gene · 694 words

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Pathway Diagram

graph TD
    ERCC1["ERCC1"]
    Longevity{"Longevity"}
    ERCC1 -->|"therapeutic target"| Longevity
    Aging{"Aging"}
    ERCC1 -->|"therapeutic target"| Aging
    Ms{"Ms"}
    ERCC1 -->|"associated with"| Ms
    Cardiac{"Cardiac"}
    ERCC1 -->|"therapeutic target"| Cardiac
    Osteoporosis{"Osteoporosis"}
    ERCC1 -->|"associated with"| Osteoporosis
    ERCC1 -->|"activates"| Aging
    Pi3K(["Pi3K"])
    ERCC1 -->|"therapeutic target"| Pi3K
    Apoptosis(["Apoptosis"])
    ERCC1 -->|"therapeutic target"| Apoptosis
    EFNB1["EFNB1"]
    ERCC1 -->|"therapeutic target"| EFNB1
    EXERCISE["EXERCISE"]
    ERCC1 -->|"activates"| EXERCISE
    ERCC1 -->|"activates"| EFNB1
    AGING["AGING"]
    ERCC1 -->|"activates"| AGING
    EFNB1 -->|"therapeutic target"| ERCC1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| ERCC1
    P21["P21"]
    P21 -->|"activates"| ERCC1
    AND["AND"]
    AND -->|"inhibits"| ERCC1
    AGING -->|"activates"| ERCC1
    EXERCISE -->|"activates"| ERCC1
    EFNB1 -->|"activates"| ERCC1
    style ERCC1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (27)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ERCC1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Aging	activates	disease	0.65
Osteoporosis	associated_with	disease	0.65
Longevity	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Pi3K	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
AND	inhibits	gene	0.60
APOPTOSIS	activates	gene	0.60
P21	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
EXERCISE	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
AGING	therapeutic_target	gene	0.60
Endothelial	therapeutic_target	cell_type	0.60
T Cell	inhibits	cell_type	0.60
EFNB1	activates	gene	0.60
EFNB1	therapeutic_target	gene	0.60
Ras	therapeutic_target	protein	0.60
EXERCISE	activates	gene	0.60
AGING	activates	gene	0.60
Apoptosis	activates	pathway	0.60
T Cell	expressed_in	cell_type	0.55
Endothelial Cell	expressed_in	cell_type	0.55

Incoming (12)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ERCC1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
EFNB1	activates	gene	0.60
AGING	activates	gene	0.60
EXERCISE	activates	gene	0.60
PI3K	therapeutic_target	gene	0.60
P21	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
APOPTOSIS	activates	gene	0.60
P21	therapeutic_target	gene	0.60
EFNB1	therapeutic_target	gene	0.60
EXERCISE	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ERCC1 in their description or question text

No additional research found