concept

ISCHEMIC STROKE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ISCHEMIC STROKE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

289Connections

0Hypotheses

0Analyses

20Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	ISCHEMIC STROKE
Key Genes/Proteins	ALZHEIMER, AMPK, amyotrophic lateral sclerosis, ANXA1, arf1
Related Diseases	aging, Alzheimer'S Disease, atherosclerosis

Pathway Diagram

graph TD
    ISCHEMIC_STROKE["ISCHEMIC STROKE"]
    style ISCHEMIC_STROKE fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ISCHEMIC_STROKE -->|"causes"| Neuroinflammation["Neuroinflammation"]
    ISCHEMIC_STROKE -->|"causes"| Blood_Brain_Barrier_Disruption["Blood-Brain Barrier Disruption"]
    ISCHEMIC_STROKE -->|"upregulates"| IFI27L2A([IFI27L2A])
    ISCHEMIC_STROKE -->|"causes"| blood_brain_barrier_integrity["blood-brain barrier integrity"]
    ISCHEMIC_STROKE -->|"causes"| neuronal_cell_death["neuronal cell death"]
    ISCHEMIC_STROKE -->|"causes"| neuroinflammation["neuroinflammation"]
    Gnetupendin_A["Gnetupendin A"] -.->|"protects against"| ISCHEMIC_STROKE
    PI3K_AKT["PI3K/AKT"] -->|"regulates"| ISCHEMIC_STROKE
    Triolein["Triolein"] -->|"treats"| ISCHEMIC_STROKE
    Tissue_Plasminogen_Activator{"Tissue Plasminogen Activator"} -->|"treats"| ISCHEMIC_STROKE
    Lipid_nanoparticles{"Lipid nanoparticles"} -->|"treats"| ISCHEMIC_STROKE
    Rehmannioside_A["Rehmannioside A"] -.->|"protects against"| ISCHEMIC_STROKE
    Excitotoxicity["Excitotoxicity"] -->|"contributes to"| ISCHEMIC_STROKE
    Remote_Ischemic_Conditioning["Remote Ischemic Conditioning"] -.->|"protects against"| ISCHEMIC_STROKE
    KLF11["KLF11"] -.->|"protects against"| ISCHEMIC_STROKE
    B_glomerulata{"B.glomerulata"} -->|"treats"| ISCHEMIC_STROKE

Outgoing (20)

Target	Relation	Type	Str
Neuroinflammation	causes	process	0.95
Blood-Brain Barrier Disruption	causes	process	0.95
Cerebral Edema	causes	disease	0.95
neuroinflammatory cascade	associated_with	process	0.90
IFI27L2A	upregulates	gene	0.90
Microglia	activates	cell_type	0.90
Amyloid-beta	promotes	compound	0.85
blood-brain barrier integrity	causes	process	0.70
neuronal cell death	causes	process	0.70
Reactive oxygen species	associated_with	process	0.70
neuroinflammation	causes	process	0.70
ENDOTHELIAL CELLS	inhibits	concept	0.50
MTOR SIGNALING	regulates	concept	0.50
NUCLEUS	associated_with	concept	0.50
EXTRACELLULAR VESICLES	regulates	concept	0.50
STEM CELLS	regulates	concept	0.50
ENDOTHELIAL CELLS	regulates	concept	0.50
ENDOTHELIAL CELLS	associated_with	concept	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
CENTRAL NERVOUS SYSTEM	causes	concept	0.50

Incoming (269)

Source	Relation	Type	Str
PLAT	treats	protein	0.95
Triolein	treats	compound	0.95
GW201	protects_against	compound	0.95
116B	treats	compound	0.95
Gnetupendin A	protects_against	compound	0.95
Vagus Nerve Stimulation	protects_against	process	0.95
PI3K/AKT	regulates	pathway	0.95
Astrocytic Glycophagy	contributes_to	process	0.93
Neuroinflammation	associated_with	process	0.92
Excitotoxicity	contributes_to	process	0.90
Glymphatic Dysfunction	contributes_to	mechanism	0.90
B.glomerulata	treats	drug	0.90
KLF11	protects_against	entity	0.90
Remote Ischemic Conditioning	protects_against	process	0.90
Rehmannioside A	protects_against	compound	0.90
Lipid nanoparticles	treats	drug	0.90
Zinc Finger Proteins	therapeutic_target	protein	0.90
cerebral edema	associated_with	disease	0.90
neuroexcitotoxicity	contributes_to	process	0.90
oxidative stress	contributes_to	phenotype	0.90
CLEC7A	associated_with	gene	0.90
Nmda Receptor	contributes_to	receptor	0.90
Tissue Plasminogen Activator	treats	drug	0.90
Asparagine Endopeptidase	protects_against	protein	0.90
CMPK2	contributes_to	gene	0.90
C1Q	associated_with	entity	0.90
TAZ	protects_against	gene	0.90
Ruxolitinib	protects_against	drug	0.90
Inflammation	causes	process	0.85
Ceramide	associated_with	compound	0.85
MicroRNAs	biomarker_for	biomarker	0.85
Long Non-Coding RNAs	biomarker_for	biomarker	0.85
Colonoscopy	causes	process	0.85
Litebamine	treats	compound	0.85
C1Q	associated_with	gene	0.85
BHB	treats	compound	0.85
Inflammatory Response	contributes_to	process	0.85
Oxidative Stress	contributes_to	process	0.85
Middle Cerebral Artery Occlusion/Reperfusion	associated_with	process	0.85
TFEB	associated_with	gene	0.85
LGALS9	biomarker_for	protein	0.85
Ion Channel Dysfunction	associated_with	mechanism	0.85
Dysregulated ZFPs	drives	protein	0.85
Β-Hydroxybutyrate	treats	compound	0.85
GW201	treats	compound	0.85
cGAMP	treats	compound	0.85
Cgamp	treats	compound	0.85
Asparagine Endopeptidase Inhibition	protects_against	process	0.80
tPA	causes	drug	0.80
Mrna Nanoparticles	treats	drug	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ISCHEMIC STROKE in their description or question text

No additional research found