gene

CFLAR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CFLAR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

14Outgoing

13Incoming

0Experiments

0Debates

Summary

CFLAR encodes c-FLIP, a critical regulator of apoptosis and necroptosis pathways with significant implications for neurodegenerative diseases and cancer therapy.

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🧬 Gene Info

Gene Symbol	CFLAR
Full Name	CASP8 and FADD-like apoptosis regulator
Chromosome	2q33.1
Function	Key death receptors include
Molecular Weight	55 kDa
Exons	13
Pathways	NF-κB Signaling, NF-κB signaling, NF-κB
UniProt ID	O15519
Ensembl ID	ENSG00000003402
OMIM	603598
GeneCards	CFLAR
Human Protein Atlas	CFLAR
Associated Diseases	Ms
Interactions	RNF31
KG Connections	27 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CFLAR — AlphaFold O15519 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CFLAR

gene · 2704 words

→

CFLAR Protein

protein · 879 words

→

Pathway Diagram

graph TD
    CFLAR["CFLAR"]
    Ms{"Ms"}
    CFLAR -->|"associated with"| Ms
    CFLAR -->|"expressed in"| Ms
    RIPK1["RIPK1"]
    CFLAR -->|"associated with"| RIPK1
    NFH["NFH"]
    CFLAR -->|"associated with"| NFH
    TNFRSF1A["TNFRSF1A"]
    CFLAR -->|"associated with"| TNFRSF1A
    IKBKB["IKBKB"]
    CFLAR -->|"associated with"| IKBKB
    Akt(["Akt"])
    CFLAR -->|"associated with"| Akt
    AUTOPHAGY["AUTOPHAGY"]
    CFLAR -->|"expressed in"| AUTOPHAGY
    APOPTOSIS["APOPTOSIS"]
    CFLAR -->|"expressed in"| APOPTOSIS
    VEGFA["VEGFA"]
    CFLAR -->|"expressed in"| VEGFA
    AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"]
    CFLAR -->|"expressed in"| AUTOPHAGY_RELATED_GENES
    Apoptosis(["Apoptosis"])
    CFLAR -->|"expressed in"| Apoptosis
    BCL2L1["BCL2L1"]
    BCL2L1 -->|"associated with"| CFLAR
    CASP1["CASP1"]
    CASP1 -->|"associated with"| CFLAR
    NFKBIA["NFKBIA"]
    NFKBIA -->|"associated with"| CFLAR
    CASP8["CASP8"]
    CASP8 -->|"associated with"| CFLAR
    IL1B["IL1B"]
    IL1B -->|"associated with"| CFLAR
    XIAP["XIAP"]
    XIAP -->|"associated with"| CFLAR
    AKT1["AKT1"]
    AKT1 -->|"associated with"| CFLAR
    STAT3["STAT3"]
    STAT3 -->|"associated with"| CFLAR
    FAS["FAS"]
    FAS -->|"expressed in"| CFLAR
    MIRNAS["MIRNAS"]
    MIRNAS -->|"associated with"| CFLAR
    RELA["RELA"]
    RELA -->|"expressed in"| CFLAR
    ATF6["ATF6"]
    ATF6 -->|"expressed in"| CFLAR
    style CFLAR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (14)

Target	Relation	Type	Str
Ms	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
RNF31	interacts_with	protein	0.63
APOPTOSIS	expressed_in	gene	0.60
Apoptosis	expressed_in	pathway	0.60
Autophagy	expressed_in	pathway	0.60
AUTOPHAGY-RELATED GENES	expressed_in	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
Akt	associated_with	pathway	0.60
VEGFA	expressed_in	gene	0.60
RIPK1	associated_with	gene	0.60
NFH	associated_with	gene	0.60
TNFRSF1A	associated_with	gene	0.60
IKBKB	associated_with	gene	0.60

Incoming (13)

Source	Relation	Type	Str
TNFA	regulates	protein	0.60
BCL2L1	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
NFKBIA	associated_with	gene	0.60
CASP8	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
XIAP	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
FAS	expressed_in	gene	0.60
RELA	expressed_in	gene	0.60
ATF6	expressed_in	gene	0.60
MIRNAS	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CFLAR in their description or question text

No additional research found