gene 2,121 words KG: TNFR1
Contents

TNFRSF1A Gene

🧬 Gene Info
Gene SymbolTNF Receptor Superfamily Member 1A
AliasesTNFRSF1A (TNFR1)
Chromosome12p13.31
Protein TypeReceptor
Functionis a member of the tumor necrosis factor receptor superfamily.
Molecular Weight55 kDa
Amino Acids455 aa
Exons10
PathwaysNF-κB, MAPK pathway
UniProt IDP19438
NCBI Gene ID7132
Associated DiseasesALS, Alzheimer, Neurodegeneration, Neuroinflammation, Parkinson
InteractionsActin, ALS, ALZHEIMER, AMYOTROPHIC LATERAL SCLEROSIS, AND, ANXIETY
KG Connections387 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Multi-Modal Stress Response Harmonization
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
PARP1 Inhibition Therapy
Score: 0.74

Related Analyses (6)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Astrocytes
cell · KG edge: expressed_in
Amyotrophic Lateral Sclerosis
redirect · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
Astrocytes
entity · KG edge: expressed_in
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: expressed_in

Knowledge Graph (12 edges)

GFAP regulates TNFR1
TNF expressed_in TNFR1
TNFR2 expressed_in TNFR1
TNFR1 expressed_in TNF
TNFR1 regulates GFAP
ATG3 regulates TNFR1
IRF1 activates TNFR1
TNF activates TNFR1
STAT1 activates TNFR1
RB1CC1 regulates TNFR1

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