gene

NFH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

4Outgoing

10Incoming

0Experiments

0Debates

Summary

NFH is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, associated with, therapeutic target. Associated with Ms. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NFH
Chromosome	22q12.2
Function	is a neuronal intermediate filament protein encoded by the NEFH gene on chromosome 22q12.
Molecular Weight	200 kDa
Amino Acids	816 aa
Exons	4
GeneCards	NFH
Human Protein Atlas	NFH
NF-L (Light)	~61 kDa
NF-M (Medium)	~102 kDa
NF-H (Heavy)	~200 kDa
Associated Diseases	neurodegeneration
KG Connections	14 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

Neurofilament Heavy Chain (NfH)

biomarker · 1103 words

→

Neurofilament Heavy Chain (NFH)

protein · 635 words

→

Pathway Diagram

graph TD
    NFH["NFH"]
    Ms{"Ms"}
    NFH -->|"therapeutic target"| Ms
    TNFRSF1A["TNFRSF1A"]
    NFH -->|"biomarker for"| TNFRSF1A
    IKBKB["IKBKB"]
    NFH -->|"associated with"| IKBKB
    Akt(["Akt"])
    NFH -->|"biomarker for"| Akt
    neurodegeneration["neurodegeneration"]
    NFH -->|"implicated in"| neurodegeneration
    BCL2L1["BCL2L1"]
    BCL2L1 -->|"biomarker for"| NFH
    CASP1["CASP1"]
    CASP1 -->|"associated with"| NFH
    NFKBIA["NFKBIA"]
    NFKBIA -->|"associated with"| NFH
    CASP8["CASP8"]
    CASP8 -->|"biomarker for"| NFH
    IL1B["IL1B"]
    IL1B -->|"associated with"| NFH
    XIAP["XIAP"]
    XIAP -->|"biomarker for"| NFH
    AKT1["AKT1"]
    AKT1 -->|"biomarker for"| NFH
    STAT3["STAT3"]
    STAT3 -->|"biomarker for"| NFH
    CFLAR["CFLAR"]
    CFLAR -->|"associated with"| NFH
    RIPK1["RIPK1"]
    RIPK1 -->|"associated with"| NFH
    style NFH fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

Target	Relation	Type	Str
Ms	therapeutic_target	disease	0.65
Akt	biomarker_for	pathway	0.60
TNFRSF1A	biomarker_for	gene	0.60
IKBKB	associated_with	gene	0.60

Incoming (10)

Source	Relation	Type	Str
BCL2L1	biomarker_for	gene	0.60
CASP1	associated_with	gene	0.60
NFKBIA	associated_with	gene	0.60
CASP8	biomarker_for	gene	0.60
IL1B	associated_with	gene	0.60
XIAP	biomarker_for	gene	0.60
AKT1	biomarker_for	gene	0.60
STAT3	biomarker_for	gene	0.60
CFLAR	associated_with	gene	0.60
RIPK1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NFH in their description or question text

No additional research found