gene

ARNT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ARNT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

368Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ARNT is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, expressed in. Associated with ALS, Aging, Als. Connected to 196 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ARNT
Full Name	Aryl Hydrocarbon Receptor Nuclear Translocator
Protein Type	Gene
Function	ARNT is an essential transcriptional cofactor
Pathways	Akt, Apoptosis, Autophagy, Cell Cycle, Circadian Rhythm
GeneCards	ARNT
Human Protein Atlas	ARNT
Hypoxia response	Heterodimerizes with HIF1α and HIF2α to activate hypoxia-responsive genes
Circadian clock	Partners with CLOCK and BMAL1 in the circadian transcriptional complex
Xenobiotic response	Works with aryl hydrocarbon receptor (AHR)
Development	Critical for embryonic development, especially vascular formation
Associated Diseases	Aging, ALS, Alzheimer, Atherosclerosis, Cancer, Cardiac
Interactions	AHR, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ANXIETY
KG Connections	368 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ARNT["ARNT"] -->|"expressed in"| Cancer["Cancer"]
    ARNT["ARNT"] -->|"expressed in"| Cardiovascular["Cardiovascular"]
    ARNT["ARNT"] -->|"expressed in"| Metabolic_Syndrome["Metabolic Syndrome"]
    ARNT["ARNT"] -->|"expressed in"| Obesity["Obesity"]
    ARNT["ARNT"] -->|"expressed in"| Ms["Ms"]
    ARNT["ARNT"] -->|"expressed in"| Diabetes["Diabetes"]
    AHR["AHR"] -->|"interacts"| ARNT["ARNT"]
    CRY["CRY"] -->|"expressed in"| ARNT["ARNT"]
    BMAL1["BMAL1"] -->|"expressed in"| ARNT["ARNT"]
    CLOCK["CLOCK"] -->|"expressed in"| ARNT["ARNT"]
    style ARNT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (244)

Target	Relation	Type	Str
circadian regulation	participates_in	pathway	0.75
Autoimmune	regulates	disease	0.65
Aging	regulates	disease	0.65
Metabolic Syndrome	expressed_in	disease	0.65
Als	regulates	disease	0.65
Fibrosis	activates	disease	0.65
Cardiac	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Diabetes	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Cancer	activates	disease	0.65
Tumor	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Diabetes	expressed_in	disease	0.65
Cardiac	inhibits	disease	0.65
ALS	inhibits	disease	0.65
ALS	regulates	disease	0.65
Senescence	regulates	disease	0.65
ALS	activates	disease	0.65
Als	activates	disease	0.65
Carcinoma	activates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Ischemia	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Obesity	activates	disease	0.65
Lymphoma	inhibits	disease	0.65
Ms	activates	disease	0.65
Parkinson	associated_with	disease	0.65
Cardiovascular	activates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Ischemia	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Obesity	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Hepatitis	regulates	disease	0.65

Incoming (124)

Source	Relation	Type	Str
NPAS3	binds	protein	0.80
AHR	interacts_with	gene	0.64
GENES	activates	gene	0.60
ERK	regulates	gene	0.60
GENES	regulates	gene	0.60
CLDN4	inhibits	gene	0.60
APOPTOSIS	activates	gene	0.60
AGING	expressed_in	gene	0.60
AGING	regulates	gene	0.60
HIPPO	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
CANCER	regulates	gene	0.60
CIRCADIAN RHYTHM	associated_with	gene	0.60
MITOPHAGY	inhibits	gene	0.60
AND	expressed_in	gene	0.60
CIRCADIAN OUTPUT GENES	expressed_in	gene	0.60
RUNX2	expressed_in	gene	0.60
CIRCADIAN RHYTHM	activates	gene	0.60
INSULIN RESISTANCE	activates	gene	0.60
CANCER	activates	gene	0.60
INFLAMMATION	regulates	gene	0.60
INSULIN RESISTANCE	regulates	gene	0.60
CANCER	expressed_in	gene	0.60
PER	expressed_in	gene	0.60
CIRCADIAN RHYTHM	regulates	gene	0.60
ROS	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
TNF-Α	regulates	gene	0.60
ANXIETY	activates	gene	0.60
MICROGLIA	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
FERROPTOSIS	regulates	gene	0.60
CLOCK GENE	expressed_in	gene	0.60
AND	activates	gene	0.60
AND	regulates	gene	0.60
CLOCK GENE	regulates	gene	0.60
YAP	regulates	gene	0.60
AND	associated_with	gene	0.60
WNT	regulates	gene	0.60
MAPK	regulates	gene	0.60
HIF-1Α	inhibits	gene	0.60
HIF	inhibits	gene	0.60
MAPK	expressed_in	gene	0.60
HIF-1Α	regulates	gene	0.60
HIF	activates	gene	0.60
CLOCK GENE	activates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
CLOCK GENE	associated_with	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
CCNA1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ARNT in their description or question text

No additional research found