gene

CRY1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CRY1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

214Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

CRY1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, regulates, activates. Associated with ALS, Als, Alzheimer. Connected to 147 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CRY1
Full Name	Cryptochrome Circadian Regulator 1
Chromosome	12q24.31
Function	Transcriptional Activation: CLOCK and BMAL1 proteins form a heterodimer that activates transcription of period (PER) and cryptochrome (CRY) genes
Primary Expression	Ubiquitous (high in brain, liver, retina)
Molecular Weight	66 kDa
Amino Acids	500 aa
Pathways	Akt, Circadian Rhythm, Lipid Metabolism, Mtor, Nf-Κb
UniProt ID	Q9UQL6
NCBI Gene ID	1399
Ensembl ID	ENSG00000012048
OMIM	601033
GeneCards	CRY1
Human Protein Atlas	CRY1
Photoreception	CRY1 detects blue light (~450 nm) through its FAD cofactor
Associated Diseases	Als, Depression, Stroke
Interactions	AKT, AMPK, ANXIETY, App, APP, BDNF
KG Connections	214 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CRY1 — AlphaFold Q9UQL6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CRY1 Gene

gene · 879 words

→

CRY1 Protein

protein · 664 words

→

Pathway Diagram

graph TD
    CRY1["CRY1"]
    CRY1 -->|"regulates"| Inflammation["Inflammation"]
    CRY1 -->|"activates"| Anxiety["Anxiety"]
    CRY1 -->|"activates"| Als["Als"]
    CRY1 -->|"regulates"| Tumor["Tumor"]
    CRY1 -->|"activates"| Depression["Depression"]
    CRY1 -->|"regulates"| Ms["Ms"]
    TNF["TNF"] -->|"regulates"| CRY1
    ARNT["ARNT"] -->|"regulates"| CRY1
    BMAL1["BMAL1"] -->|"regulates"| CRY1
    CLOCK["CLOCK"] -->|"activates"| CRY1
    MTOR["MTOR"] -->|"regulates"| CRY1
    FASN["FASN"] -->|"regulates"| CRY1
    PER3["PER3"] -->|"expressed in"| CRY1
    PER1["PER1"] -->|"expressed in"| CRY1
    ICAM1["ICAM1"] -->|"activates"| CRY1

Outgoing (151)

Target	Relation	Type	Str
Circadian Rhythm Regulation	involved_in	process	0.90
Circadian Rhythm Disruption	involved_in	process	0.90
circadian regulation	participates_in	pathway	0.85
Als	activates	disease	0.75
Inflammation	regulates	disease	0.75
Alzheimer	expressed_in	disease	0.75
PER2	expressed_in	gene	0.70
Circadian Rhythm	regulates	pathway	0.70
CIRCADIAN RHYTHM	expressed_in	gene	0.70
magnetic_field_detection	mediates	mechanism	0.70
Circadian Rhythm	expressed_in	pathway	0.70
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Ms	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Type 2 Diabetes	regulates	disease	0.65
Stroke	associated_with	disease	0.65
Leukemia	interacts_with	disease	0.65
Depression	associated_with	disease	0.65
Fibrosis	regulates	disease	0.65
Metabolic Syndrome	interacts_with	disease	0.65
Diabetes	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
PER2	activates	gene	0.65
Obesity	activates	disease	0.65
CRY2	activates	gene	0.65
PER1	activates	gene	0.65
Anxiety	contributes_to	disease	0.65
Tumor	regulates	disease	0.65
Ms	regulates	disease	0.65
Depression	activates	disease	0.65
Anxiety	activates	disease	0.65
BMAL1	inhibits	gene	0.60
BMAL1	activates	gene	0.60
AKT	regulates	gene	0.60
NAMPT	regulates	gene	0.60
PER2	regulates	gene	0.60
SIRT1	regulates	gene	0.60
CLOCK	regulates	gene	0.60
IBA1	activates	gene	0.60
Rb	activates	protein	0.60

Incoming (63)

Source	Relation	Type	Str
proteins-cry1-protein	describes	wiki	1.00
Chronic Sleep Deprivation	causes	process	0.90
APP/PS1	expressed_in	gene	0.70
CLOCK	activates	gene	0.70
CLOCK	associated_with	gene	0.70
PER1	expressed_in	gene	0.70
BMAL1	regulates	gene	0.60
PER3	expressed_in	gene	0.60
BMAL1	activates	gene	0.60
BMAL1	expressed_in	gene	0.60
CRY2	expressed_in	gene	0.60
CLOCK	expressed_in	gene	0.60
CLOCK	interacts_with	gene	0.60
ARNT	regulates	gene	0.60
APP	expressed_in	gene	0.60
BMAL1	inhibits	gene	0.60
CLOCK	inhibits	gene	0.60
IBA1	activates	gene	0.60
AMYLOID-BETA	expressed_in	gene	0.60
AMYLOID	expressed_in	gene	0.60
CLOCK GENE	expressed_in	gene	0.60
BMAL1	associated_with	gene	0.60
CLOCK GENES	expressed_in	gene	0.60
PER3	associated_with	gene	0.60
PER1	associated_with	gene	0.60
PER1	regulates	gene	0.60
TLR2	regulates	gene	0.60
PI3K	expressed_in	gene	0.60
MTOR	expressed_in	gene	0.60
PER2	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
CIRCADIAN RHYTHM	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
MTOR	regulates	gene	0.60
FASN	regulates	gene	0.60
TNF	regulates	gene	0.60
ALZHEIMER'S DISEASE NEUROPATHOLOGY	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
PER	inhibits	gene	0.60
CIRCADIAN RHYTHM	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
ICAM1	activates	gene	0.60
TNFRSF1A	activates	gene	0.60
OCLN	regulates	gene	0.60
TAU	expressed_in	gene	0.60
MTOR	activates	gene	0.60
APP	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What neural circuits encode and maintain multi-generational migratory route memo

spatial memory | 2026-04-08 | 7 hypotheses Top: 0.455

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The paper describes memory-based migration routes maintained across generations

closed · Rounds: 4 · Score: 0.95 · 2026-04-09

Related Research

Hypotheses and analyses mentioning CRY1 in their description or question text

No additional research found