Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | IL1 |
| Key Genes/Proteins | CSF1R, IFN, IL6, IL6R, NLRP3, NTRK2 |
| Related Diseases | Cognitive Impairment |
| Related Pathways | NFkB, NF-kB signaling |
Knowledge base pages for this entity
graph TD
IL1[IL1]
IL1 -->|activates| Immune_Cell_Activation[Immune Cell Activation]
IL1 -->|expressed in| Neutrophils[Neutrophils]
IL1 -->|causes| Blood_Brain_Barrier[Blood-Brain Barrier]
IL1 -->|expressed in| Microglia[Microglia]
IL1 -->|involved_in| Neuroinflammation[Neuroinflammation]
IL1 -->|inhibits| TNF[TNF]
IL1 -->|interacts| NFkB[NFkB]
IL1 -->|inhibits| NLRP3[NLRP3]
IL1 -->|inhibits| NTRK2[NTRK2]
CSF1R[CSF1R] -->|inhibits| IL1
IFN[IFN] -->|activates| IL1| Target | Relation | Type | Str |
|---|---|---|---|
| Immune Cell Activation | activates | process | 0.95 |
| Pro-inflammatory Cytokine Production | associated_with | process | 0.95 |
| Blood-Brain Barrier | causes | cell_type | 0.90 |
| Microglia | expressed_in | cell_type | 0.90 |
| Neutrophils | expressed_in | cell_type | 0.90 |
| Cognitive Impairment | associated_with | phenotype | 0.85 |
| Neuroinflammation | involved_in | process | 0.85 |
| NFkB | interacts_with | pathway | 0.80 |
| TNF | inhibits | gene | 0.80 |
| NTRK2 | inhibits | gene | 0.60 |
| NLRP3 | inhibits | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| T cells | expressed_in | cell_type | 0.60 |
| senescence | participates_in | pathway | 0.60 |
| microglia | expressed_in | cell_type | 0.60 |
| IL6 | inhibits | gene | 0.60 |
| IL6R | inhibits | gene | 0.60 |
| IL6R | associated_with | gene | 0.60 |
| TNFRSF1A | associated_with | gene | 0.60 |
| IL6R | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning IL1 in their description or question text
No additional research found