gene

SP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

160Connections

2Hypotheses

0Analyses

50Outgoing

48Incoming

0Experiments

0Debates

Summary

SP1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, activates, associated with. Associated with ALS, Aging, Als. Connected to 105 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SP1
Full Name	SP1 (Specificity Protein 1)
Aliases	Specificity Protein 1
Protein Type	Gene
Function	The SP1 gene encodes Specificity Protein 1 (Sp1), a zinc finger transcription factor that binds to GC-rich promoter elements and regulates the expression of numerous genes including housekeeping genes
Pathways	Akt, Epigenetic, Pi3K
GeneCards	SP1
Human Protein Atlas	SP1
GC-box	5'-GGGGCGG-3' sequences in gene promoters
GT-box	Similar regulatory elements
Gene Expression Regulation	Controls numerous neuronal genes including those involved in synaptic function
Cell Survival	Exhibits anti-apoptotic functions through regulation of Bcl-2 family genes
Amyloid Processing	Directly regulates APP and BACE1 expression
[Tau](/proteins/tau) Phosphorylation	Influences tau metabolism through transcriptional regulation
Associated Diseases	Als, Alzheimer, Ms
Known Drugs/Compounds	Glucosamine
Interactions	AND, APP, ATP2A3, CANCER, CHOP, DKK1
KG Connections	159 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SP1["SP1"]
    SP1 -->|"activates"| Cancer["Cancer"]
    SP1 -->|"activates"| Ms["Ms"]
    SP1 -->|"activates"| Als["Als"]
    SP1 -->|"expressed in"| Tumor["Tumor"]
    CLCN1["CLCN1"] -->|"regulates"| SP1
    SP3["SP3"] -->|"expressed in"| SP1
    ATP2A3["ATP2A3"] -->|"interacts"| SP1
    PI3K["PI3K"] -->|"regulates"| SP1
    SPHK1["SPHK1"] -->|"activates"| SP1
    ERK["ERK"] -->|"activates"| SP1
    AGING["AGING"] -->|"regulates"| SP1
    FOS["FOS"] -->|"target for"| SP1
    HIPPO["HIPPO"] -->|"expressed in"| SP1
    RELA["RELA"] -->|"expressed in"| SP1

Outgoing (112)

Target	Relation	Type	Str
ATP2A3	activates	gene	0.95
ATP2A3	binds	gene	0.95
Obesity	activates	disease	0.65
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	regulates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Inflammation	contributes_to	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	activates	disease	0.65
Leukemia	activates	disease	0.65
Hypertension	expressed_in	disease	0.65
Cardiovascular	activates	disease	0.65
Carcinoma	biomarker_for	disease	0.65
Cancer	biomarker_for	disease	0.65
Als	inhibits	disease	0.65
Aging	regulates	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	activates	disease	0.65
Ataxia	expressed_in	disease	0.65
ATM	regulates	gene	0.60
MAOB	associated_with	gene	0.60
RPS6KB1	biomarker_for	gene	0.60
CHD4	biomarker_for	gene	0.60
HSF1	activates	gene	0.60
STAT3	activates	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
Oxidative Stress	expressed_in	pathway	0.60
SP3	expressed_in	gene	0.60
ATP2A3	interacts_with	gene	0.60
FOXO1	regulates	gene	0.60
HDAC6	regulates	gene	0.60
HDAC1	regulates	gene	0.60
EZH2	regulates	gene	0.60
CANCER	regulates	gene	0.60
Epigenetic	regulates	pathway	0.60
AND	regulates	gene	0.60

Incoming (48)

Source	Relation	Type	Str
Glucosamine	modulates	compound	0.80
CLCN1	regulates	gene	0.70
APP	activates	gene	0.60
TREM2	contributes_to	gene	0.60
SOD2	contributes_to	gene	0.60
CXCL1	contributes_to	gene	0.60
LRRK2	activates	gene	0.60
CXCL1	implicated_in	gene	0.60
REG3A	implicated_in	gene	0.60
SOD2	implicated_in	gene	0.60
LRRK2	interacts_with	gene	0.60
LRRK2	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
SP3	expressed_in	gene	0.60
ATP2A3	interacts_with	gene	0.60
PI3K	regulates	gene	0.60
SPHK1	activates	gene	0.60
FOS	therapeutic_target	gene	0.60
RELA	expressed_in	gene	0.60
MYC	expressed_in	gene	0.60
ATP7A	expressed_in	gene	0.60
SOD1	expressed_in	gene	0.60
DUSP10	associated_with	gene	0.60
MAP1S	associated_with	gene	0.60
PSP	associated_with	gene	0.60
EGR1	expressed_in	gene	0.60
EGR1	activates	gene	0.60
CHOP	activates	gene	0.60
SMAD2	regulates	gene	0.60
STAT3	activates	gene	0.60
ATP2A3	activates	entity	0.60
NESTIN	activates	gene	0.60
DKK1	inhibits	gene	0.60
DNA	interacts_with	gene	0.60
AND	activates	gene	0.60
PROTEIN MISFOLDING	activates	gene	0.60
P53	expressed_in	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
CANCER	activates	entity	0.60
AND	expressed_in	gene	0.60
ERK	activates	gene	0.60
AGING	regulates	gene	0.60
HIPPO	expressed_in	gene	0.60
MIRNAS	biomarker_for	gene	0.60
SGMS1	activates	gene	0.55

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
USP14 Inhibition to Accelerate Proteasomal Degradation of Sy	0.481	proteomics	Quantitative proteomics of the aging syn
FSP1/CoQ10 Axis as GPX4-Independent Neuroprotective Pathway	0.480	neurodegeneration	Can ferroptosis inhibitors prevent BBB d

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SP1 in their description or question text

No additional research found

SP1

Understanding Entity Pages

Summary

Wiki Pages (21)

SP1 (Specificity Protein 1)

CASP12 (Caspase-12)

CASP14 Gene

CASP12 Gene — Cysteine-Containing Aspartate-Specific Protease 12

USP13 Inhibitor for Mitophagy and Synaptic Proteostasis

CASP1 Gene

CASP10 Gene

FSP1-CoQ10 Redox Augmentation Therapy for Neurodegeneration

USP13 Deubiquitinase Inhibition for Parkin-Independent Mitophagy Rescue

DUSP11 Gene

USP14 Gene

DUSP10 Gene

DUSP1 Gene

FSP1/AIFM2 (Ferroptosis Suppressor Protein 1)

DUSP12 Gene

Caspase-1 (CASP1)

USP19 Protein

USP14 Protein

USP10 Protein

FSP1 Gene - Ferroptosis Suppressor Protein 1

DUSP1 Protein