protein 787 words KG: FSP1
Contents

FSP1/AIFM2 (Ferroptosis Suppressor Protein 1)

🔬 Protein Info
Gene SymbolFSP1
Full NameFerroptosis Suppressor Protein 1 (Apoptosis-Inducing Factor Mitochondrial 2)
AliasesPage for FSP1 Gene, Page for FSP1 Protein
Chromosome10q22.1
Protein TypeOxidoreductase
FunctionTraps lipid peroxyl radicals: Direct radical-scavenging
Molecular Weight35 kDa
PathwaysDifferentiation, Ferroptosis, Lipid Metabolism, Oxidative Stress
UniProt ID[Q9NSW9](https://www.uniprot.org/uniprot/Q9NSW9)
Ensembl IDENSG00000185730
GeneCardsFSP1
Human Protein AtlasFSP1
FAD-binding domainBinds flavin adenine dinucleotide cofactor
NAD(P)H-binding siteElectron donor binding
Associated DiseasesALS, Alzheimer, Cancer, Gastric Cancer, Huntington, multiple sclerosis
Known Drugs/CompoundsDEX
InteractionsACSL4, ALZHEIMER, AMYOTROPHIC LATERAL SCLEROSIS, AND, App, ATP
KG Connections238 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (10)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.85
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69

Related Analyses (11)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Ferroptosis Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (8)

Amyotrophic Lateral Sclerosis
redirect · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: therapeutic_target
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: associated_with
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: regulates
BACH1 — BTB Domain and CNC Homolog 1
gene · KG edge: inhibits

Knowledge Graph (12 edges)

DEX activates FSP1
PIEZO1 activates FSP1
KCNK2 activates FSP1
TRPC1 activates FSP1
TRPV4 activates FSP1
NRF2 contributes_to FSP1
FSP1 activates KCNK2
FSP1 activates TRPV4
GPX4 interacts_with FSP1
NRF2 interacts_with FSP1

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