| Gene Symbol | CASP10 |
| Chromosome | 2q33.3 |
| Function | is an initiator caspase that transduces death signals from cell surface receptors to the intracellular cell death machinery[@caspase2020]. |
| Amino Acids | 521 aa |
| Ensembl ID | ENSG00000127334 |
| GeneCards | CASP10 |
| Human Protein Atlas | CASP10 |
| Pro-apoptotic | In some contexts, CASP10 can initiate apoptosis through the extrinsic pathway |
| Anti-apoptotic | CASP10 can also inhibit necroptosis by cleaving key necroptotic proteins, particularly when CASP8 is deficient[@necroptosis2023] |
| Neuronal Apoptosis | CASP10 is activated by amyloid-beta (Aβ) toxicity through death receptor pathways, leading to synaptic loss and neuronal death. |
| Tau Pathology | CASP10 can cleave tau protein, generating truncated fragments that may promote neurofibrillary tangle formation. |
| Neuroinflammation | CASP10 participates in inflammatory signaling cascades involving NF-κB, amplifying microglial activation and cytokine production[@nfkb2022]. |
| Synaptic Dysfunction | CASP10 activation contributes to the loss of synaptic proteins including PSD-95 and synaptophysin, correlating with cognitive decline[@synaptic2018]. |
| α-Synuclein Toxicity | Oligomeric α-synuclein activates death receptors, recruiting CASP10 to initiate apoptosis. |
| Oxidative Stress | Increased reactive oxygen species (ROS) sensitize neurons to death receptor signaling. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!