Contents

Caspase-1 (CASP1)

🔬 Protein Info

Gene Symbol	CASPASE1
Function	Caspase-1 (interleukin-1β-converting enzyme, ICE) is the prototypical inflammatory caspase, playing a central role in innate immunity and inflammatory cell death (pyroptosis)
Subcellular Localization	Cytosol, inflammasome complex
Molecular Weight	45 kDa (pro-form), 20/10 kDa (cleaved subunits)
UniProt ID	[P29466](https://www.uniprot.org/uniprot/P29466)
GeneCards	CASPASE1
Human Protein Atlas	CASPASE1
IL-33	Processed to active form (context-dependent)
Associated Diseases	ALS
KG Connections	10 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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