protein 2,702 words KG: CASP12PROTEIN
Contents

CASP12 (Caspase-12)

🔬 Protein Info
Gene SymbolCASP12
Full NameCysteine-Containing Aspartate-Specific Protease 12
Chromosome11q22.2
Functionis a typical inactive zymogen consisting of
Primary ExpressionPrimarily in brain, muscle, and peripheral tissues
Amino Acids341 aa
UniProt IDQ9Y252
NCBI Gene ID100506658
Ensembl IDENSG00000244045
OMIM602394
GeneCardsCASP12
Human Protein AtlasCASP12
Associated DiseasesAlzheimer's disease, Parkinson's disease, ALS
DatabasesGeneCardsHPASTRING

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Related Hypotheses (19)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Microbial Inflammasome Priming Prevention
Score: 0.65
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.54

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (3)

Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40
Microbiome-Gut Barrier Signatures in ALS — Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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