gene

DUSP10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DUSP10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

0Analyses

29Outgoing

10Incoming

0Experiments

0Debates

Summary

DUSP10 is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, therapeutic target. Associated with Als, Alzheimer, Ms. Connected to 20 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DUSP10
Protein Type	Phosphatase
Function	is a member of the dual-specificity phosphatase family that specifically dephosphorylates and inactivates both JNK (c-Jun N-terminal Kinase) and p38 MAPK pathways.
Amino Acids	482 aa
Pathways	MAPK, MAPK pathway
Ensembl ID	ENSG00000143507
GeneCards	DUSP10
Human Protein Atlas	DUSP10
N-terminal Non-catalytic Domain	Contains binding sites for MAPK substrates and regulators
Phosphatase Catalytic Domain	Contains the HCX5R active site motif essential for phosphatase activity
Nuclear Export Signal (NES)	Allows shuttling between nucleus and cytoplasm
Associated Diseases	Als, Alzheimer, Ms
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, MAPK, MICROGLIA
KG Connections	39 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DUSP10 Gene

gene · 1018 words

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Pathway Diagram

graph TD
    DUSP10["DUSP10"]
    Alzheimer{"Alzheimer"}
    DUSP10 -->|"associated with"| Alzheimer
    Als{"Als"}
    DUSP10 -->|"associated with"| Als
    Ms{"Ms"}
    DUSP10 -->|"associated with"| Ms
    MAP1S["MAP1S"]
    DUSP10 -->|"associated with"| MAP1S
    PSP["PSP"]
    DUSP10 -->|"associated with"| PSP
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    DUSP10 -->|"associated with"| ALZHEIMER_S_DISEASE
    ASTROCYTES["ASTROCYTES"]
    DUSP10 -->|"associated with"| ASTROCYTES
    SP1["SP1"]
    DUSP10 -->|"associated with"| SP1
    APOE["APOE"]
    DUSP10 -->|"associated with"| APOE
    TAU["TAU"]
    DUSP10 -->|"associated with"| TAU
    KIF13A["KIF13A"]
    DUSP10 -->|"associated with"| KIF13A
    TRIM24["TRIM24"]
    DUSP10 -->|"associated with"| TRIM24
    style DUSP10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

Target	Relation	Type	Str
Ms	associated_with	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Ms	activates	disease	0.65
SP1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
TAU	associated_with	gene	0.60
KIF13A	associated_with	gene	0.60
TRIM24	associated_with	gene	0.60
STX6	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
NEUROTOXICITY	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Tau Phosphorylation	activates	pathway	0.60
MAP1S	associated_with	gene	0.60
Mapk	activates	pathway	0.60
PSP	associated_with	gene	0.60
TAU	activates	gene	0.60
MOBP	regulates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
Apoptosis	inhibits	pathway	0.60
EIF2AK3	regulates	gene	0.60
MAPT	regulates	gene	0.60
PSP	regulates	gene	0.60
STX6	regulates	gene	0.60

Incoming (10)

Source	Relation	Type	Str
APOE	regulates	gene	0.60
P38	activates	gene	0.60
AND	activates	gene	0.60
MIRNAS	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
GENES	therapeutic_target	gene	0.60
MAPK	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
MICROGLIA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DUSP10 in their description or question text

No additional research found