gene

SPHK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPHK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

213Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SPHK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in, expressed in. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 124 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SPHK1
Full Name	Sphingosine Kinase 1
Chromosome	17q25.1
Protein Type	Kinase
Function	### Sphingolipid Rheostat
Primary Expression	Hippocampus, Cortex, Cerebellum, White matter (widespread)
Molecular Weight	42.5 kDa
Exons	6
Pathways	NF-κB
UniProt ID	Q9NYA1
NCBI Gene ID	8877
Ensembl ID	ENSG00000176884
OMIM	603730
GeneCards	SPHK1
Human Protein Atlas	SPHK1
Associated Diseases	Als, Atherosclerosis, Cardiac, Cardiovascular, Fibrosis, Heart Failure
Known Drugs/Compounds	rapamycin
Interactions	Actin, ALS, ALS-CAUSING MUTATIONS, AND, ASTROCYTE, ASTROCYTES
KG Connections	213 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SPHK1 — AlphaFold Q9NYA1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SPHK1 — Sphingosine Kinase 1

gene · 1441 words

→

SPHK1 Protein

protein · 569 words

→

Pathway Diagram

graph TD
    SPHK1["SPHK1"]
    SPHK1 -->|"participates in"| Cardiovascular["Cardiovascular"]
    SPHK1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    SPHK1 -->|"activates"| Ms["Ms"]
    SPHK1 -->|"activates"| Dementia["Dementia"]
    SPHK1 -->|"activates"| Als["Als"]
    SPHK1 -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    SPHK1 -->|"activates"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    SPHK1 -->|"activates"| Ftd["Ftd"]
    SPHK1 -->|"activates"| Leukemia["Leukemia"]
    PTEN["PTEN"] -->|"activates"| SPHK1
    MAP1LC3["MAP1LC3"] -->|"activates"| SPHK1
    ALS_CAUSING_MUTATIONS["ALS-CAUSING MUTATIONS"] -->|"activates"| SPHK1
    ATG["ATG"] -->|"activates"| SPHK1
    TFEB["TFEB"] -->|"activates"| SPHK1
    GENES["GENES"] -->|"activates"| SPHK1
    DNA["DNA"] -->|"activates"| SPHK1
    VCP["VCP"] -->|"activates"| SPHK1
    ICAM1["ICAM1"] -->|"activates"| SPHK1

Outgoing (142)

Target	Relation	Type	Str
Inflammation	activates	disease	0.75
Heart Failure	regulates	disease	0.65
Hypertension	regulates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Heart Failure	implicated_in	disease	0.65
Hypertension	implicated_in	disease	0.65
Ftd	activates	disease	0.65
Colorectal Cancer	activates	disease	0.65
Dementia	activates	disease	0.65
Leukemia	activates	disease	0.65
ALS	activates	disease	0.65
Cardiac	implicated_in	disease	0.65
Cardiac	regulates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Atherosclerosis	implicated_in	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
Myocardial Infarction	implicated_in	disease	0.65
Ischemia	activates	disease	0.65
Stroke	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Fibrosis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Als	activates	disease	0.65
MAP1LC3	activates	gene	0.60
LPCAT3	interacts_with	gene	0.60
Unfolded Protein Response	activates	pathway	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
Nf-Κb	activates	pathway	0.60
Sphingolipid	implicated_in	pathway	0.60
Mapk	implicated_in	pathway	0.60
ERK	regulates	gene	0.60
Autophagy	activates	pathway	0.60
Sphingolipid	activates	pathway	0.60
NEUROINFLAMMATION	activates	gene	0.60
NF-ΚB	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
Tdp-43	activates	pathway	0.60
Autophagy	interacts_with	pathway	0.60
Proteasome	activates	pathway	0.60
AUTOPHAGY	activates	gene	0.60

Incoming (71)

Source	Relation	Type	Str
CHMP2B	activates	gene	0.60
MTOR	activates	gene	0.60
LC3	activates	gene	0.60
OVERVIEW	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
VALOSIN	activates	gene	0.60
TBK1	activates	gene	0.60
PINK1	activates	gene	0.60
TARDBP	activates	gene	0.60
STAT3	activates	gene	0.60
TLR4	activates	gene	0.60
GSS	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
NRF2	expressed_in	gene	0.60
GFAP	expressed_in	gene	0.60
GBA	regulates	gene	0.60
CAV1	regulates	gene	0.60
GENES	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
rapamycin	targets	drug	0.60
INFLAMMATION	activates	gene	0.60
CANCER	activates	gene	0.60
NF-ΚB	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
STROKE	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
FTD	activates	entity	0.60
ICAM1	activates	gene	0.60
NLRP3	activates	gene	0.60
MAP1LC3	activates	gene	0.60
ALS-CAUSING MUTATIONS	activates	gene	0.60
ATG	activates	gene	0.60
GENES	activates	gene	0.60
DNA	activates	gene	0.60
ALS-CAUSING MUTATIONS	therapeutic_target	gene	0.60
NEURON	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ALS	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
DEMENTIA	activates	gene	0.60
IL-6	activates	gene	0.60
PTEN	activates	gene	0.60
TFEB	activates	gene	0.60
VCP	activates	gene	0.60
STAT3	implicated_in	gene	0.60
AKT	implicated_in	gene	0.60
APOPTOSIS	implicated_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SPHK1 in their description or question text

No additional research found