gene

STX6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STX6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections

0Hypotheses

0Analyses

11Outgoing

31Incoming

0Experiments

0Debates

Summary

STX6 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Alzheimer, Ms. Connected to 15 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	STX6
Protein Type	Receptor
Function	Syntaxin 6 is a Q-SNARE protein localized primarily to the trans-Golgi network (TGN) and endosomes.
Subcellular Localization	primarily to the trans-Golgi network (TGN) and endosomes
Ensembl ID	ENSG00000139334
GeneCards	STX6
Human Protein Atlas	STX6
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Ms, neurodegeneration
KG Connections	42 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

STX6 Gene

gene · 569 words

→

Pathway Diagram

graph TD
    STX6["STX6"]
    Alzheimer{"Alzheimer"}
    STX6 -->|"associated with"| Alzheimer
    Als{"Als"}
    STX6 -->|"associated with"| Als
    Ms{"Ms"}
    STX6 -->|"associated with"| Ms
    MAPT["MAPT"]
    STX6 -->|"associated with"| MAPT
    neurodegeneration["neurodegeneration"]
    STX6 -->|"implicated in"| neurodegeneration
    DUSP10["DUSP10"]
    DUSP10 -->|"associated with"| STX6
    MAP1S["MAP1S"]
    MAP1S -->|"associated with"| STX6
    PSP["PSP"]
    PSP -->|"associated with"| STX6
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| STX6
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"associated with"| STX6
    SP1["SP1"]
    SP1 -->|"associated with"| STX6
    APOE["APOE"]
    APOE -->|"associated with"| STX6
    TAU["TAU"]
    TAU -->|"associated with"| STX6
    KIF13A["KIF13A"]
    KIF13A -->|"associated with"| STX6
    TRIM24["TRIM24"]
    TRIM24 -->|"associated with"| STX6
    style STX6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

Target	Relation	Type	Str
Creutzfeldt-Jakob Disease	therapeutic_target	disease	0.80
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer's disease	causes	disease	0.60
Parkinson's disease	causes	disease	0.60
ALS	causes	disease	0.60
MAPT	associated_with	gene	0.60
TREM2	causes	gene	0.60
neurodegeneration	causes	disease	0.60
oxidative stress response	participates_in	pathway	0.60

Incoming (31)

Source	Relation	Type	Str
PSP	regulates	gene	0.70
MAPT	regulates	gene	0.70
MOBP	regulates	gene	0.70
BST1	causes	gene	0.60
CR2	causes	gene	0.60
ERBB1	causes	gene	0.60
GPNMB	causes	gene	0.60
IL34	causes	gene	0.60
PILRA	causes	gene	0.60
SHARPIN	causes	gene	0.60
RUNX2	regulates	gene	0.60
MOBP	causes	gene	0.60
ATXN3	causes	gene	0.60
RUNX2	causes	gene	0.60
PSP	causes	gene	0.60
APOE	regulates	gene	0.60
DUSP10	regulates	gene	0.60
C4A	regulates	gene	0.60
EIF2AK3	regulates	gene	0.60
C4A	causes	gene	0.60
DUSP10	associated_with	gene	0.60
MAP1S	associated_with	gene	0.60
PSP	associated_with	gene	0.60
SP1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
TAU	associated_with	gene	0.60
KIF13A	associated_with	gene	0.60
TRIM24	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
B4GALNT1	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning STX6 in their description or question text

No additional research found