gene

REG3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about REG3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

10Outgoing

5Incoming

0Experiments

0Debates

Summary

Page for REG3A — Regenerating Family Member 3 Alpha

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	REG3A
Full Name	Regenerating Family Member 3 Alpha
Chromosome	2p12
Function	is a secreted C-type lectin belonging to the Reg family of proteins.
Molecular Weight	16 kDa
Amino Acids	175 aa
Pathways	NF-κB
UniProt ID	Q9NZU5
NCBI Gene ID	64084
Ensembl ID	ENSG00000138231
GeneCards	REG3A
Human Protein Atlas	REG3A
Associated Diseases	Stroke
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: REG3A — AlphaFold Q9NZU5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

REG3A — Regenerating Family Member 3 Alpha

gene · 1199 words

→

REG3A Protein

protein · 1502 words

→

Pathway Diagram

graph TD
    REG3A["REG3A"]
    Inflammation["Inflammation"]
    REG3A -->|"contributes_to"| Inflammation
    Oxidative_Stress["Oxidative Stress"]
    REG3A -->|"contributes_to"| Oxidative_Stress
    Complement["Complement"]
    REG3A -->|"associated_with"| Complement
    Immune_Response["Immune Response"]
    REG3A -->|"associated_with"| Immune_Response
    TREM2["TREM2"]
    TREM2 -->|"contributes_to"| REG3A
    SOD2["SOD2"]
    SOD2 -->|"contributes_to"| REG3A
    CXCL1["CXCL1"]
    CXCL1 -->|"contributes_to"| REG3A
    SP1["SP1"]
    SP1 -->|"contributes_to"| REG3A
    neurodegeneration["neurodegeneration"]
    REG3A -->|"implicated_in"| neurodegeneration
    style REG3A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
Inflammation	contributes_to	disease	0.65
Oxidative Stress	contributes_to	pathway	0.60
Complement	associated_with	pathway	0.60
Immune Response	associated_with	pathway	0.60
SOD2	implicated_in	gene	0.60
SP1	implicated_in	gene	0.60
SPOCK2	implicated_in	gene	0.60
TREM2	implicated_in	gene	0.60
oxidative stress response	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.55

Incoming (5)

Source	Relation	Type	Str
TREM2	contributes_to	gene	0.60
SOD2	contributes_to	gene	0.60
CXCL1	contributes_to	gene	0.60
SP1	contributes_to	gene	0.60
CXCL1	implicated_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning REG3A in their description or question text

No additional research found