gene

CLCN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLCN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

25Outgoing

6Incoming

0Experiments

0Debates

Summary

CLCN1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, interacts with. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	Chloride Voltage-Gated Channel 1
Chromosome	7q34
Protein Type	Channel
Function	CLC-1 is a homodimeric voltage-gated chloride channel belonging to the CLC chloride channel family.
Primary Expression	Skeletal muscle (type I and type II fibers)
Amino Acids	994 aa
Pathways	insulin signaling
UniProt ID	P35523
NCBI Gene ID	1187
Ensembl ID	ENSG00000100137
OMIM	118425
Muscle excitability	Maintains the resting membrane potential in skeletal muscle fibers
Chloride conductance	Provides the majority of resting conductance in muscle
Repolarization	Helps terminate muscle action potentials
Volume regulation	Contributes to cell volume homeostasis
Associated Diseases	Muscle weakness, Myotonia, neurodegeneration
Known Drugs/Compounds	NMD670
Interactions	FKBP8, GSK3β, Hsp90β
KG Connections	31 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CLCN1 — AlphaFold P35523 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CLCN1 (Chloride Voltage-Gated Channel 1)

gene · 1841 words

→

CLCN10 — Chloride Voltage-Gated Channel 10

gene · 4939 words

→

Pathway Diagram

graph TD
    CLCN1["CLCN1"]
    Muscle_excitability["Muscle excitability"]
    CLCN1 -->|"regulates"| Muscle_excitability
    Myotonia["Myotonia"]
    CLCN1 -->|"causes"| Myotonia
    CUGBP1["CUGBP1"]
    CLCN1 -->|"regulates"| CUGBP1
    GSK3_["GSK3beta"]
    CLCN1 -->|"interacts with"| GSK3_
    Manumycin_A["Manumycin A"]
    CLCN1 -->|"upregulates"| Manumycin_A
    NMD670["NMD670"]
    CLCN1 -->|"inhibits"| NMD670
    Hsp90_["Hsp90beta"]
    CLCN1 -->|"interacts with"| Hsp90_
    FKBP8["FKBP8"]
    CLCN1 -->|"interacts with"| FKBP8
    Neuromuscular_transmission["Neuromuscular transmission"]
    CLCN1 -->|"regulates"| Neuromuscular_transmission
    Muscle_weakness["Muscle weakness"]
    CLCN1 -->|"associated with"| Muscle_weakness
    CryAB["CryAB"]
    CLCN1 -->|"associated with"| CryAB
    Sp1["Sp1"]
    CLCN1 -->|"regulates"| Sp1
    style CLCN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CLCN1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Myotonia	causes	phenotype	0.90
Muscle excitability	regulates	biological_process	0.90
GSK3β	interacts_with	protein	0.80
CUGBP1	regulates	protein	0.80
Manumycin A	upregulates	drug	0.80
NMD670	inhibits	drug	0.80
Hsp90β	interacts_with	protein	0.80
FKBP8	interacts_with	protein	0.80
Neuromuscular transmission	regulates	biological_process	0.80
Muscle weakness	associated_with	phenotype	0.80
Cullin 4	degrades	protein	0.70
CryAB	associated_with	gene	0.70
IR	associated_with	gene	0.70
neurodegeneration	causes	disease	0.70
Sp1	regulates	transcription_factor	0.70
MBNL1	associated_with	gene	0.60
MTMR1	associated_with	gene	0.60
INSR	causes	gene	0.55
MBNL1	causes	gene	0.55
insulin signaling	participates_in	pathway	0.55
RNA	protects_against	gene	0.55
INSR	protects_against	gene	0.55
DMPK	causes	gene	0.55

Incoming (6)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CLCN1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
ARRB2	causes	gene	0.70
BIN1	causes	gene	0.70
CD2AP	causes	gene	0.70
ATP2A1	protects_against	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CLCN1 in their description or question text

No additional research found