gene 1,018 words KG: DUSP10
Contents

DUSP10 Gene

🧬 Gene Info
Gene SymbolDUSP10
Protein TypePhosphatase
Functionis a member of the dual-specificity phosphatase family that specifically dephosphorylates and inactivates both JNK (c-Jun N-terminal Kinase) and p38 MAPK pathways.
Amino Acids482 aa
PathwaysMAPK, MAPK pathway
Ensembl IDENSG00000143507
GeneCardsDUSP10
Human Protein AtlasDUSP10
N-terminal Non-catalytic DomainContains binding sites for MAPK substrates and regulators
Phosphatase Catalytic DomainContains the HCX5R active site motif essential for phosphatase activity
Nuclear Export Signal (NES)Allows shuttling between nucleus and cytoplasm
Associated DiseasesAls, Alzheimer, Ms
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, MAPK, MICROGLIA
KG Connections39 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

Astrocytes
cell · KG edge: associated_with
Progressive Supranuclear Palsy (PSP)
disease · KG edge: associated_with
Apoptosis in Neurodegeneration
entity · KG edge: activates
Astrocytes
entity · KG edge: associated_with
KIF13A Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

DUSP10 associated_with MAP1S
DUSP10 associated_with PSP
DUSP10 associated_with SP1
DUSP10 associated_with APOE
DUSP10 associated_with TAU
DUSP10 associated_with KIF13A
DUSP10 associated_with TRIM24
DUSP10 associated_with STX6
DUSP10 associated_with MAPT
P38 activates DUSP10

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