gene

VAMP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VAMP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

77Connections

0Hypotheses

2Analyses

32Outgoing

45Incoming

0Experiments

3Debates

Summary

VAMP2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, co discussed. Associated with Aging, Als, Dementia. Connected to 18 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	VAMP2
Aliases	Page for VAMP2 Gene, Synaptobrevin-2
Chromosome	17p13.1
Protein Type	Protein
Function	Vesicle Docking: VAMP2 on vesicles pairs with syntaxin-1A on plasma membrane
Molecular Weight	12.6 kDa
Amino Acids	116 aa
Exons	5
UniProt ID	P60880
GeneCards	VAMP2
Human Protein Atlas	VAMP2
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	AGING, ALPHA-SYNUCLEIN, AMYLOID, AND, APOE, APOE3
KG Connections	77 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: VAMP2 — AlphaFold P60880 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VAMP2["VAMP2"]
    Dementia{"Dementia"}
    VAMP2 -->|"regulates"| Dementia
    Parkinson{"Parkinson"}
    VAMP2 -->|"regulates"| Parkinson
    Complement(["Complement"])
    VAMP2 -->|"interacts with"| Complement
    neurodegeneration["neurodegeneration"]
    VAMP2 -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"regulates"| VAMP2
    APOE3["APOE3"]
    APOE3 -->|"interacts with"| VAMP2
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"interacts with"| VAMP2
    APOE4["APOE4"]
    APOE4 -->|"interacts with"| VAMP2
    APOE["APOE"]
    APOE -->|"interacts with"| VAMP2
    style VAMP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (32)

Target	Relation	Type	Str
Neurodegeneration	interacts_with	disease	0.65
Parkinson	regulates	disease	0.65
Dementia	regulates	disease	0.65
Schizophrenia	inhibits	disease	0.65
Aging	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Depression	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Parkinson	interacts_with	disease	0.65
Chaperone	interacts_with	pathway	0.60
Synaptic Transmission	interacts_with	pathway	0.60
Neuron	inhibits	cell_type	0.60
BCL-2	expressed_in	gene	0.60
autophagy pathway	participates_in	pathway	0.60
BAX	expressed_in	gene	0.60
SNAP25	expressed_in	gene	0.60
GAP43	expressed_in	gene	0.60
TRKB	expressed_in	gene	0.60
VGF	regulates	gene	0.60
Complement	interacts_with	pathway	0.60
NEURODEGENERATION	interacts_with	gene	0.60
ALPHA-SYNUCLEIN	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
Α-Synuclein	associated_with	protein	0.60
PSD95	expressed_in	gene	0.60
Cortex	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
CEREBRAL CORTEX	activates	concept	0.50
SYNTAXIN-1	activates	protein	0.50
SNAP-25	activates	protein	0.50
SNARE	activates	protein	0.50
Cortex	activates	brain_region	0.50

Incoming (45)

Source	Relation	Type	Str
SQSTM1	associated_with	gene	0.70
SYN1	associated_with	gene	0.70
SNAP25	associated_with	gene	0.70
SYT1	associated_with	gene	0.70
PSEN1	associated_with	gene	0.70
IBA1	regulates	gene	0.70
AIF1	regulates	gene	0.70
APP	regulates	gene	0.70
ATG7	regulates	gene	0.70
GFAP	regulates	gene	0.70
GRIN2B	associated_with	gene	0.70
AND	activates	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60
ALPHA-SYNUCLEIN	interacts_with	gene	0.60
DEPRESSION	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
AMYLOID	interacts_with	gene	0.60
CORTEX	interacts_with	brain_region	0.60
SNARE	activates	gene	0.60
NEURONS	activates	cell_type	0.60
APOE	interacts_with	gene	0.60
STX1A	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
ATG5	regulates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
APOE3	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
AGING	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
NEURON	co_discussed	cell_type	0.60
AD	regulates	gene	0.60
AUTOPHAGY	regulates	pathway	0.60
AΒ	regulates	gene	0.60
BDNF	causes	gene	0.60
NEURON	activates	cell_type	0.60
APOE4	interacts_with	gene	0.60
NEURON	expresses	cell_type	0.60
SNAP25	interacts_with	gene	0.55
SNARE	interacts_with	gene	0.55
BDNF	co_discussed	gene	0.45
PSD95	co_discussed	gene	0.40
TAU	co_discussed	gene	0.40
SNAP25	co_discussed	gene	0.40
GAP43	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What is the therapeutic window between tau propagation inhibition and essential

neurodegeneration | 2026-04-06 | 5 hypotheses Top: 0.780

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

VAMP2

Understanding Entity Pages

Summary

Wiki Pages (5)

VAMP2 Protein

VAMP2 Gene - Synaptobrevin-2

VAMP2 Protein

SYNAPTOBREVIN-2 Protein (VAMP2)

VAMP2 — Synaptobrevin-2

Pathway Diagram

Outgoing (32)

Incoming (45)

Targeting Hypotheses (0)

Mentioning Analyses (2)

What is the therapeutic window between tau propagation inhibition and essential

Tau propagation mechanisms and therapeutic interception points

Experiments (0)

Related Papers (0)

Debates (3)

The debate highlighted that most promising targets (VAMP2, ESCRT, fascin-1) are

Investigate prion-like spreading of tau pathology through connected brain region

Tau propagation mechanisms and therapeutic interception points