gene

SHANK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SHANK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

21Outgoing

6Incoming

0Experiments

0Debates

Summary

Page for SHANK2 Gene

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🧬 Gene Info

Gene Symbol	SHANK2
Chromosome	11q13.2
Protein Type	Scaffold Protein
Function	The SHANK2 gene encodes a scaffold protein involved in various neurological processes:
Primary Expression	dendritic spines where it organizes the postsynaptic machinery, regulating synaptic transmission and plasticity
Subcellular Localization	s. The genomic organization includes a proline-rich region, ankyrin repeat domains, SH3 domain, and PDZ domains, each me
Amino Acids	630 aa
Pathways	Apoptosis
UniProt ID	Q9UQB8
NCBI Gene ID	22941
Ensembl ID	ENSG00000141013
GeneCards	SHANK2
Human Protein Atlas	SHANK2
Associated Diseases	neurodegeneration
KG Connections	27 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SHANK2 — AlphaFold Q9UQB8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SHANK2["SHANK2"]
    SHANK2 -->|"target for"| Ischemia["Ischemia"]
    SHANK2 -->|"target for"| Stroke["Stroke"]
    SHANK2 -->|"target for"| Als["Als"]
    SHANK2 -->|"expressed in"| SYN1["SYN1"]
    SHANK2 -->|"target for"| APOPTOSIS["APOPTOSIS"]
    SHANK2 -->|"expressed in"| PRKACB["PRKACB"]
    SHANK2 -->|"expressed in"| PSD95["PSD95"]
    SHANK2 -->|"expressed in"| Synaptic_Plasticity["Synaptic Plasticity"]
    SYT1["SYT1"] -->|"expressed in"| SHANK2
    STROKE["STROKE"] -->|"target for"| SHANK2
    BCL_2["BCL-2"] -->|"expressed in"| SHANK2
    BDNF["BDNF"] -->|"expressed in"| SHANK2

Outgoing (21)

Target	Relation	Type	Str
Stroke	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Stroke	activates	disease	0.65
Ischemia	activates	disease	0.65
Apoptosis	activates	pathway	0.60
Neuron	therapeutic_target	cell_type	0.60
Bdnf	expressed_in	protein	0.60
SYT1	expressed_in	gene	0.60
Synaptic Plasticity	expressed_in	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
APOPTOSIS	therapeutic_target	gene	0.60
CREB1	expressed_in	gene	0.60
SYN1	expressed_in	gene	0.60
PRKACB	expressed_in	gene	0.60
PSD95	expressed_in	gene	0.60
SHANK3	regulates	gene	0.55
Cortex	expressed_in	brain_region	0.55
Hippocampus	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (6)

Source	Relation	Type	Str
SYT1	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
PSD95	expressed_in	gene	0.60
BAX	expressed_in	gene	0.60
STROKE	therapeutic_target	gene	0.60
BCL-2	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SHANK2 in their description or question text

No additional research found