gene

MMP14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MMP14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

25Outgoing

8Incoming

0Experiments

0Debates

Summary

MMP14 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, inhibits, implicated in. Associated with Inflammation, Sepsis. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MMP14
Aliases	Matrix Metalloproteinase 14
Function	MMP14 serves multiple physiological functions
Molecular Weight	63 kDa
Pathways	Mapk, Apoptosis, Nf-Κb
UniProt ID	[P50281](https://www.uniprot.org/uniprot/P50281)
NCBI Gene ID	4323
GeneCards	MMP14
Human Protein Atlas	MMP14
Propeptide domain	Maintains enzyme latency via cysteine switch
Catalytic domain	Contains zinc-binding motif (HELGH)
Hemopexin-like domain	Mediates substrate recognition
Transmembrane domain	Anchors protein to cell membrane
Cytoplasmic tail	Regulates intracellular trafficking[@strongin1995]
Neuroinflammation	Upregulated in reactive astrocytes around amyloid plaques, contributing to inflammatory milieu.[@wilcock2011]
Associated Diseases	neurodegeneration
Interactions	AND, APOPTOSIS, INFLAMMATION, MMP9, TNF, TNF-Α
KG Connections	33 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MMP14 (Matrix Metalloproteinase 14)

gene · 956 words

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Pathway Diagram

graph TD
    MMP14["MMP14 (MT1-MMP)"]
    TNF["TNF-alpha"]
    NFKB["NF-kappaB"]
    MAPK3["MAPK3 (ERK1)"]
    EGFR["EGFR"]
    PRKACA["PKA catalytic subunit"]
    MMP9["MMP9"]
    INFLAMMATION_GENE["Inflammatory genes"]
    APOPTOSIS_GENE["Apoptotic genes"]
    INFLAMMATION_DIS["Neuroinflammation"]
    APOPTOSIS_PATH["Neuronal apoptosis"]
    MAPK_PATH["MAPK signaling"]
    NFKB_PATH["NF-kappaB pathway"]
    SEPSIS["Sepsis"]
    NEURODEGENERATION["Neurodegeneration"]

    MMP14 -->|"inhibits"| TNF
    MMP14 -->|"therapeutic target"| NFKB
    MMP14 -->|"therapeutic target"| MAPK3
    MMP14 -->|"therapeutic target"| EGFR
    MMP14 -->|"therapeutic target"| PRKACA
    MMP14 -->|"inhibits"| MMP9
    MMP14 -->|"inhibits"| INFLAMMATION_GENE
    MMP14 -->|"inhibits"| APOPTOSIS_GENE
    MMP14 -->|"inhibits"| INFLAMMATION_DIS
    MMP14 -->|"inhibits"| APOPTOSIS_PATH
    MMP14 -->|"therapeutic target"| MAPK_PATH
    MMP14 -->|"therapeutic target"| NFKB_PATH
    MMP14 -->|"therapeutic target"| SEPSIS
    MMP14 -->|"implicated in"| NEURODEGENERATION

    INFLAMMATION_GENE -->|"feedback inhibits"| MMP14
    APOPTOSIS_GENE -->|"feedback inhibits"| MMP14

    style MMP14 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style TNF fill:#ef5350,stroke:#333,stroke-width:2px
    style INFLAMMATION_DIS fill:#ef5350,stroke:#333,stroke-width:2px
    style APOPTOSIS_PATH fill:#ef5350,stroke:#333,stroke-width:2px
    style NEURODEGENERATION fill:#7d4200,stroke:#333,stroke-width:2px
    style SEPSIS fill:#7d4200,stroke:#333,stroke-width:2px
    style NFKB fill:#4a1a6b,stroke:#333,stroke-width:2px
    style MAPK3 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style EGFR fill:#4a1a6b,stroke:#333,stroke-width:2px
    style PRKACA fill:#4a1a6b,stroke:#333,stroke-width:2px
    style MMP9 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style INFLAMMATION_GENE fill:#4a1a6b,stroke:#333,stroke-width:2px
    style APOPTOSIS_GENE fill:#4a1a6b,stroke:#333,stroke-width:2px
    style MAPK_PATH fill:#1b5e20,stroke:#333,stroke-width:2px
    style NFKB_PATH fill:#1b5e20,stroke:#333,stroke-width:2px

Outgoing (25)

Target	Relation	Type	Str
Sepsis	therapeutic_target	disease	0.65
Inflammation	inhibits	disease	0.65
MMP9	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
TIMP1	expressed_in	gene	0.60
APOPTOSIS	inhibits	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
INFLAMMATION	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
Nf-Κb	therapeutic_target	pathway	0.60
MMP2	expressed_in	gene	0.60
Mapk	therapeutic_target	pathway	0.60
Apoptosis	inhibits	pathway	0.60
TNF	inhibits	gene	0.60
MAPK3	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
PRKACA	therapeutic_target	gene	0.60
MMP9	inhibits	gene	0.60
SMAD	expressed_in	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
TGF-beta signaling	participates_in	pathway	0.60
MMP9	co_expressed_with	gene	0.50
MMP2	co_expressed_with	gene	0.50

Incoming (8)

Source	Relation	Type	Str
MAPK3	therapeutic_target	gene	0.60
PRKACA	therapeutic_target	gene	0.60
INFLAMMATION	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
AND	inhibits	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
AKT	expressed_in	gene	0.60
AKT	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MMP14 in their description or question text

No additional research found