concept

ACSL5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACSL5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

80Connections

0Hypotheses

0Analyses

50Outgoing

24Incoming

0Experiments

0Debates

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💡 Concept Info

Name	ACSL5
Key Genes/Proteins	ABCA1, ABCB1, Actin, ALS, AND, App
Related Diseases	Cancer, Carcinoma
Related Pathways	autophagy pathway, cholesterol homeostasis

Pathway Diagram

graph TD
    ACSL5["ACSL5"]
    ACSL5 -->|"target for"| Cancer["Cancer"]
    ACSL5 -->|"activates"| Carcinoma["Carcinoma"]
    ACSL5 -->|"inhibits"| Ms["Ms"]
    ACSL5 -->|"regulates"| FERROPTOSIS["FERROPTOSIS"]
    ACSL5 -->|"target for"| SLC16A2["SLC16A2"]
    ACSL5 -->|"target for"| JUN["JUN"]
    ACSL5 -->|"target for"| GSS["GSS"]
    BAMBI["BAMBI"] -->|"regulates"| ACSL5
    WTAP["WTAP"] -->|"inhibits"| ACSL5
    GSS -->|"activates"| ACSL5
    CYP2E1["CYP2E1"] -->|"activates"| ACSL5
    JUN -->|"activates"| ACSL5
    ROS["ROS"] -->|"regulates"| ACSL5
    METTL3["METTL3"] -->|"inhibits"| ACSL5

Outgoing (56)

Target	Relation	Type	Str
Carcinoma	activates	disease	0.65
Ms	inhibits	disease	0.65
Cancer	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
FERROPTOSIS	regulates	phenotype	0.64
PPARGC1A	regulates	gene	0.60
METTL3	inhibits	gene	0.60
Wnt	inhibits	pathway	0.60
Tgf-Β	regulates	pathway	0.60
Ferroptosis	regulates	pathway	0.60
GSS	activates	gene	0.60
JUN	activates	gene	0.60
MICRORNAS	activates	gene	0.60
METTL3	activates	gene	0.60
WTAP	activates	gene	0.60
Wnt	activates	pathway	0.60
SLC16A2	associated_with	gene	0.60
CANCER	activates	gene	0.60
WTAP	inhibits	gene	0.60
MIR-375	activates	gene	0.60
AND	therapeutic_target	gene	0.60
CYP2E1	therapeutic_target	gene	0.60
MIR-375	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
CYP2E1	activates	gene	0.60
WNT	inhibits	gene	0.60
ROS	regulates	gene	0.60
AND	regulates	gene	0.60
Actin	therapeutic_target	protein	0.60
App	therapeutic_target	protein	0.60
RPL4	associated_with	gene	0.60
Ras	activates	protein	0.60
TGF-beta signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
ferroptosis	participates_in	pathway	0.60
BAMBI	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
SLC16A2	therapeutic_target	gene	0.60
ferroptosis	regulates	process	0.60
JUN	therapeutic_target	gene	0.60
GSS	therapeutic_target	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
BAMBI	regulates	gene	0.60
SMAD	regulates	gene	0.60
TGF	regulates	gene	0.60
ALS	expressed_in	gene	0.60
PKM	activates	gene	0.55
SQSTM1	activates	gene	0.55
lipid metabolism	participates_in	pathway	0.55
cholesterol homeostasis	participates_in	pathway	0.55

Incoming (24)

Source	Relation	Type	Str
miR-375	regulates	gene	0.80
BAMBI	regulates	gene	0.72
ABCB1	associated_with	gene	0.60
PEX3	associated_with	gene	0.60
VPS33A	associated_with	gene	0.60
PPP1R7	associated_with	gene	0.60
COX15	associated_with	gene	0.60
ATP	activates	gene	0.60
VPS16	associated_with	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
GSS	therapeutic_target	gene	0.60
MIR-375	therapeutic_target	gene	0.60
CYP2E1	therapeutic_target	gene	0.60
PPARGC1A	regulates	gene	0.60
JUN	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
SLC16A2	therapeutic_target	gene	0.60
WTAP	inhibits	gene	0.60
GSS	activates	gene	0.60
CYP2E1	activates	gene	0.60
JUN	activates	gene	0.60
ROS	regulates	gene	0.60
METTL3	inhibits	gene	0.60
ABCA1	activates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACSL5 in their description or question text

No additional research found