| Gene Symbol | SMAD1 |
| Full Name | SMAD Family Member 1 |
| Chromosome | 4q31.3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the central nervous system: |
| Amino Acids | 493 aa |
| Pathways | TGF-β, signaling: [@liu2006] |
| UniProt ID | Q99707 |
| NCBI Gene ID | 4093 |
| Ensembl ID | ENSG00000147853 |
| OMIM | 601595 |
| GeneCards | SMAD1 |
| Human Protein Atlas | SMAD1 |
| MH1 domain (N-terminal) | DNA-binding region that binds to specific DNA sequences (SBE - SMAD-binding element) |
| MH2 domain (C-terminal) | Protein-protein interaction domain that mediates interactions with receptors, co-SMADs, and transcriptional co-activators/repressors |
| Associated Diseases | neurodegeneration |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APP, APP/PS1, AXON |
| KG Connections | 47 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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