gene 2,543 words KG: SMAD6
Contents

SMAD6 — SMAD Family Member 6

🧬 Gene Info
Gene SymbolSMAD6
Full NameSMAD Family Member 6
Chromosome15q22.21
Protein TypeInhibitory SMAD, transcription regulator
Functionis a gene located on chromosome 15q22.
Primary ExpressionCortex, Hippocampus, Heart, Lung
PathwaysTGF-β
UniProt IDO43541
NCBI Gene ID4092
Ensembl IDENSG00000168487
OMIM607929
GeneCardsSMAD6
Human Protein AtlasSMAD6
Associated DiseasesAls, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes
InteractionsTET2
KG Connections43 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (4)

GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56

Related Analyses (2)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Notch and Gamma-Secretase Modulators for Parkinson's Di
company · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in
ATF6 - Activating Transcription Factor 6
gene · KG edge: associated_with
BMP7 Gene (Bone Morphogenetic Protein 7)
gene · KG edge: associated_with
CCL20 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

RORA associated_with SMAD6
BMP7 associated_with SMAD6
CX3CR1 associated_with SMAD6
AHR associated_with SMAD6
EP300 associated_with SMAD6
JUN associated_with SMAD6
JAK2 associated_with SMAD6
CCL20 associated_with SMAD6
CD38 associated_with SMAD6
FOXP3 associated_with SMAD6

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