| Gene Symbol | SMAD7 |
| Full Name | SMAD Family Member 7 |
| Chromosome | 18q21.1 |
| Function | is a critical inhibitory SMAD protein that negatively regulates transforming growth factor-beta (TGF-β) and bone morphogenetic protein (BMP) signaling pathways. |
| Amino Acids | 426 aa |
| Exons | 6 |
| Pathways | TGF-β, TGF-β signaling |
| UniProt ID | O15117 |
| NCBI Gene ID | 4093 |
| Ensembl ID | ENSG00000101680 |
| OMIM | 602932 |
| GeneCards | SMAD7 |
| Human Protein Atlas | SMAD7 |
| Co-repressor recruitment | Attracts histone deacetylases and other transcriptional repressors to TGF-β target genes |
| Competition for co-activators | Interferes with R-SMAD interaction with transcriptional co-activators |
| Associated Diseases | postoperative cognitive dysfunction |
| Interactions | CANCER, CDKN1A, ESRRB, GBM, JUN, MLCK |
| KG Connections | 64 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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