gene

BMPR1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BMPR1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

13Outgoing

5Incoming

0Experiments

0Debates

Summary

Page for BMPR1B Gene

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🧬 Gene Info

Gene Symbol	BMPR1B
Full Name	Bone Morphogenetic Protein Receptor Type 1B
Chromosome	4q22.3
Protein Type	Receptor
Function	BMPR1B (Bone Morphogenetic Protein Receptor Type 1B) is a serine/threonine receptor kinase that transduces signals from bone morphogenetic proteins (BMPs), which are members of the TGF-β superfamily.
Primary Expression	various brain regions and has been implicated in neurodegenerative diseases, particularly Parkinson's disease where BM
Pathways	TGF-β
UniProt ID	O00221
GeneCards	BMPR1B
Human Protein Atlas	BMPR1B
Associated Diseases	neurodegeneration
Interactions	BMP7, BMPR2, ERK, ERK1
KG Connections	18 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: BMPR1B — AlphaFold O00221 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

BMPR1B Gene

gene · 530 words

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Pathway Diagram

graph TD
    BMPR1B["BMPR1B"]
    BMPR2("BMPR2")
    BMPR1B -->|"interacts_with"| BMPR2
    BMP2(["BMP2"])
    BMPR1B -->|"participates_in"| BMP2
    BMP4(["BMP4"])
    BMPR1B -->|"participates_in"| BMP4
    SMAD("SMAD")
    BMPR1B -->|"participates_in"| SMAD
    TGF_beta(["TGF-beta"])
    BMPR1B -->|"participates_in"| TGF_beta
    Obesity{"Obesity"}
    BMPR1B -->|"inhibits"| Obesity
    BMP7["BMP7"]
    BMPR1B -->|"activates"| BMP7
    Differentiation(["Differentiation"])
    BMPR1B -->|"activates"| Differentiation
    ERK1["ERK1"]
    ERK1 -->|"inhibits"| BMPR1B
    ERK["ERK"]
    ERK -->|"inhibits"| BMPR1B
    neurodegeneration["neurodegeneration"]
    BMPR1B -->|"implicated_in"| neurodegeneration

Outgoing (13)

Target	Relation	Type	Str
BMPR2	interacts_with	protein	0.90
BMP2	participates_in	pathway	0.80
BMP4	participates_in	pathway	0.80
TGF-beta	participates_in	pathway	0.70
SMAD	participates_in	protein	0.70
Obesity	inhibits	disease	0.65
BMP7	activates	gene	0.60
TGF-beta signaling	participates_in	pathway	0.60
NOTCH3	associated_with	gene	0.60
SMAD1	associated_with	gene	0.60
SMAD4	associated_with	gene	0.60
TET2	associated_with	gene	0.60
Differentiation	activates	pathway	0.60

Incoming (5)

Source	Relation	Type	Str
ERK1	inhibits	gene	0.60
ABCC8	associated_with	gene	0.60
AQP1	associated_with	gene	0.60
BMPR1A	associated_with	gene	0.60
ERK	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BMPR1B in their description or question text

No additional research found