Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LOXL4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | LOXL4 |
| Key Genes/Proteins | HIF, LOX, LOXL1, LOXL2, LOXL3, SMAD |
| Related Diseases | Breast Cancer, Glioma |
| Related Pathways | oxidative stress response, TGF-beta signaling |
graph TD
LOXL4[LOXL4]
LOXL4 -->|involved_in| Cancer_Progression[Cancer Progression]
LOXL4 -->|promotes| tumor_progression[tumor progression]
LOXL4 -->|participates in| oxidative_stress_response[oxidative stress response]
LOXL4 -->|activates| SMAD[SMAD]
LOXL4 -->|activates| TGF[TGF]
LOXL4 -->|participates in| TGF_beta_signaling[TGF-beta signaling]
LOXL4 -->|data_in| benchmark_ot_ad_answer_key_LOX[benchmark_ot_ad_answer_key:LOXL4]
LOX[LOX] -->|activates| LOXL4
HIF[HIF] -->|activates| LOXL4
LOXL2[LOXL2] -->|activates| LOXL4
benchmark_ot_ad_answer_key_LOX -->|data_in| LOXL4| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:LOXL4 | data_in | dataset_row | 0.00 |
| Cancer Progression | involved_in | process | 0.95 |
| Cancer Progression | promotes | process | 0.95 |
| Glioma | associated_with | disease | 0.92 |
| tumor progression | promotes | process | 0.80 |
| Breast Cancer | associated_with | disease | 0.80 |
| oxidative stress response | participates_in | pathway | 0.55 |
| SMAD | activates | gene | 0.55 |
| TGF | activates | gene | 0.55 |
| TGF-beta signaling | participates_in | pathway | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:LOXL4 | data_in | dataset_row | 0.00 |
| Copper | associated_with | chemical | 0.80 |
| LOXL2 | associated_with | gene | 0.55 |
| LOXL3 | associated_with | gene | 0.55 |
| LOXL1 | associated_with | gene | 0.55 |
| LOXL2 | activates | gene | 0.55 |
| LOXL2 | targets | gene | 0.55 |
| HIF | activates | gene | 0.55 |
| LOX | associated_with | gene | 0.55 |
| LOX | activates | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning LOXL4 in their description or question text
No additional research found