protein

PRESENILIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRESENILIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1062Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PRESENILIN is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, regulates. Associated with ALS, Aging, Als. Connected to 477 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	PRESENILIN
Chromosome	14q24.2
Primary Expression	Ca1, Hippocampus, Cortex, Parietal Lobe, Gray Matter
Pathways	autophagy pathway, proteasome pathway, Oxidative Stress, Apoptosis, Autophagy
GeneCards	PRESENILIN
Human Protein Atlas	PRESENILIN
[app](/genes/app)	Generates amyloid-beta peptides of varying lengths (Aβ37–43)
E-cadherin	Cell adhesion molecule; cleavage modulates cell-cell contacts
ErbB4	Receptor tyrosine kinase; cleavage releases signaling domain
ER calcium regulation	PS1 functions as an ER calcium leak channel; FAD mutations reduce this function, increasing ER calcium stores and sensitizing neurons to calcium-dependent excitotoxicity
Wnt/β-catenin signaling	PS1 interacts with β-catenin and gsk3-beta, modulating Wnt signaling independently of Notch processing
Protein trafficking	Facilitates transport of proteins through the ER-Golgi secretory pathway
Predominantly missense mutations	Single amino acid substitutions affecting gamma-secretase processivity
Associated Diseases	Aging, Als, Alzheimer, Alzheimer Disease, Alzheimer'S Disease
Interactions	ABCD3, ACHE, Actin, ADAM10, ALS, ALZHEIMER
KG Connections	1022 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Presenilin-1 (PS1)

entity · 1985 words

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Pathway Diagram

graph TD
    PRESENILIN["PRESENILIN"] -->|"Causes"| FAMILIAL_AD["FAMILIAL_AD"]
    PRESENILIN["PRESENILIN"] -->|"Interacts With"| Dementia["Dementia"]
    PRESENILIN["PRESENILIN"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    PRESENILIN["PRESENILIN"] -->|"Interacts With"| Als["Als"]
    PRESENILIN["PRESENILIN"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    PRESENILIN["PRESENILIN"] -->|"Interacts With"| Parkinson["Parkinson"]
    PRESENILIN["PRESENILIN"] -->|"Interacts With"| Ms["Ms"]
    PRESENILIN["PRESENILIN"] -->|"Associated With"| Neurodegeneration["Neurodegeneration"]
    MFN1["MFN1"] -->|"Interacts With"| PRESENILIN["PRESENILIN"]
    DNM1L["DNM1L"] -->|"Interacts With"| PRESENILIN["PRESENILIN"]
    DDIT3["DDIT3"] -->|"Interacts With"| PRESENILIN["PRESENILIN"]
    ABCD3["ABCD3"] -->|"Interacts With"| PRESENILIN["PRESENILIN"]
    LMNA["LMNA"] -->|"Interacts With"| PRESENILIN["PRESENILIN"]
    style PRESENILIN fill:#0d47a1,color:#e0e0e0
    style FAMILIAL_AD fill:#b71c1c,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Neurodegeneration fill:#b71c1c,color:#e0e0e0
    style MFN1 fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style DDIT3 fill:#8d4900,color:#e0e0e0
    style ABCD3 fill:#8d4900,color:#e0e0e0
    style LMNA fill:#8d4900,color:#e0e0e0

Outgoing (594)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	1.00
AMYLOID	associated_with	gene	1.00
Alzheimer	therapeutic_target	disease	0.95
Als	associated_with	disease	0.95
APP	associated_with	gene	0.90
ALZHEIMER'S DISEASE	associated_with	gene	0.90
proteasome pathway	regulates	pathway	0.88
autophagy pathway	regulates	pathway	0.88
Aging	associated_with	disease	0.85
Dementia	associated_with	disease	0.85
Als	regulates	disease	0.85
AMYLOID	therapeutic_target	gene	0.80
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.80
Dementia	causes	disease	0.75
Alzheimer	activates	disease	0.75
Neurodegeneration	regulates	disease	0.75
Alzheimer	causes	disease	0.75
Neurodegeneration	associated_with	disease	0.75
Alzheimer	regulates	disease	0.75
FAMILIAL_AD	causes	disease	0.72
AMYLOID	regulates	gene	0.70
PSEN1	associated_with	gene	0.70
ALZHEIMER'S DISEASE	causes	gene	0.70
Oxidative Stress	regulates	pathway	0.70
DEMENTIA	causes	gene	0.70
CTSD	associated_with	gene	0.70
GENES	therapeutic_target	gene	0.70
APP	regulates	gene	0.70
GENES	associated_with	gene	0.70
Als	inhibits	disease	0.65
Als	protects_against	disease	0.65
Alzheimer	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Neurodegeneration	transports	disease	0.65
Dementia	interacts_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Alzheimer	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Depression	activates	disease	0.65
Parkinson	interacts_with	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Als	interacts_with	disease	0.65
Ms	expressed_in	disease	0.65
Dementia	biomarker_for	disease	0.65
Aging	causes	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Tauopathy	associated_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Als	activates	disease	0.65

Incoming (468)

Source	Relation	Type	Str
ALZHEIMER	associated_with	gene	1.00
P60TRP	inhibits	protein	0.80
ALZHEIMER	therapeutic_target	gene	0.80
ALZHEIMER'S DISEASE	associated_with	gene	0.70
OXIDATIVE STRESS	regulates	gene	0.70
NEURODEGENERATION	associated_with	gene	0.70
TAU	regulates	gene	0.70
APP	associated_with	gene	0.70
TAU	causes	gene	0.70
ALZHEIMER	causes	gene	0.70
NEURODEGENERATION	regulates	gene	0.70
PSEN2	associated_with	gene	0.70
NIX	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
TAU	inhibits	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
APP	interacts_with	gene	0.60
AMYLOID-BETA	associated_with	gene	0.60
TAU	associated_with	gene	0.60
PARKINSON	regulates	gene	0.60
EXERCISE	regulates	gene	0.60
ALPHA-SYNUCLEIN	regulates	gene	0.60
DEMENTIA	causes	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
DNA	interacts_with	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
GABA	associated_with	gene	0.60
BACE1	regulates	gene	0.60
ASTROCYTES	associated_with	gene	0.60
NOTCH	associated_with	gene	0.60
SYNAPSE	transports	gene	0.60
AMYLOID	inhibits	gene	0.60
GENES	therapeutic_target	gene	0.60
APOPTOSIS	associated_with	gene	0.60
NOTCH	activates	gene	0.60
ALZHEIMER	transports	gene	0.60
NOTCH	regulates	gene	0.60
AMYLOID	transports	gene	0.60
NOTCH	transports	gene	0.60
ASTROCYTES	activates	gene	0.60
MICROGLIA	activates	gene	0.60
SLC17A7	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRESENILIN in their description or question text

No additional research found