concept

MS4A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MS4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

77Connections

0Hypotheses

0Analyses

41Outgoing

36Incoming

0Experiments

0Debates

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💡 Concept Info

Name	MS4A
Key Genes/Proteins	ABCA7, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE, App
Related Diseases	Alzheimer, Alzheimer's disease

Wiki Pages (16)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MS4A["MS4A"]
    MS4A -->|"expressed in"| Microglia["Microglia"]
    MS4A ---|"associated"| Alzheimer["Alzheimer"]
    MS4A ---|"associated"| Neuroinflammation["Neuroinflammation"]
    MS4A ---|"associated"| Inflammation["Inflammation"]
    MS4A ---|"associated"| AND["AND"]
    MS4A ---|"associated"| CD33["CD33"]
    BIN1["BIN1"] -->|"expressed in"| MS4A
    CLU["CLU"] -->|"expressed in"| MS4A
    MICROGLIA["MICROGLIA"] -->|"expressed in"| MS4A
    CD2AP["CD2AP"] ---|"associated"| MS4A
    CR1["CR1"] ---|"associated"| MS4A
    ABCA7["ABCA7"] ---|"associated"| MS4A

Outgoing (41)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.70
Alzheimer	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
HLA	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
GENES	associated_with	gene	0.60
EPHA1	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
Neuroinflammatory	associated_with	pathway	0.60
Endocytosis	associated_with	pathway	0.60
Immune Response	associated_with	pathway	0.60
AND	associated_with	gene	0.60
CD33	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
CLU	associated_with	gene	0.60
Microglia	associated_with	cell_type	0.60
MICROGLIA	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CR1	associated_with	gene	0.60
Rb	associated_with	protein	0.60
App	associated_with	protein	0.60
NME8	interacts_with	gene	0.60
PICALM	interacts_with	gene	0.60
PTK2B	interacts_with	gene	0.60
RIN3	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
ZCWPW1	interacts_with	gene	0.60
SORL1	expressed_in	gene	0.60
microglia	expressed_in	cell_type	0.60
TREM2	regulates	gene	0.60
MS4A4A	interacts_with	gene	0.60
MS4A6A	interacts_with	gene	0.60
TGFBR2	regulates	gene	0.60
TREM2	inhibits	gene	0.60
Alzheimer's disease	inhibits	disease	0.60
PICALM	expressed_in	gene	0.60
neurons	expressed_in	cell_type	0.60
Microglia	expressed_in	cell_type	0.55

Incoming (36)

Source	Relation	Type	Str
CD2AP	associated_with	gene	0.60
CR1	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
ABCA7	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
CLU	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
EPHA1	associated_with	gene	0.60
CD33	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
ABCA7	expressed_in	gene	0.60
CD2AP	expressed_in	gene	0.60
CD33	expressed_in	gene	0.60
CR1	expressed_in	gene	0.60
EPHA1	expressed_in	gene	0.60
HLA	expressed_in	gene	0.60
ABCA7	interacts_with	gene	0.60
BIN1	interacts_with	gene	0.60
CASS4	interacts_with	gene	0.60
CD2AP	interacts_with	gene	0.60
CD33	interacts_with	gene	0.60
CELF1	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
EPHA1	interacts_with	gene	0.60
FERMT2	interacts_with	gene	0.60
HLA	interacts_with	gene	0.60
INPP5D	interacts_with	gene	0.60
MEF2C	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	disease	0.48
APOE	associated_with	gene	0.48
BIN1	expressed_in	gene	0.48
CLU	expressed_in	gene	0.48
MICROGLIA	expressed_in	cell_type	0.48
TREM2	associated_with	gene	0.48

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MS4A in their description or question text

No additional research found

MS4A

Understanding Entity Pages

Wiki Pages (16)

MS4A4A Gene — Membrane-Spanning 4-Domains A4A

MS4A6A Gene

MS4A6E Gene

MS4A4A-MS4A6A Cooperation in TREM2 Regulation

MS4A7 Gene — Membrane-Spanning 4-Domains A7

MS4A1 — Membrane Spanning 4-Domains A1 (CD20)

MS4A2 Gene (FcεRIβ)

MS4A3 Protein

MS4A3 Gene

MS4A4A/MS4A6A → TREM2 Negative Regulation → Microglial Dysfunction → AD Causal Chain

MS4A4A Protein

MS4A1 Protein

MS4A4E Gene - Membrane-Spanning 4-Domains A4E

MS4A6A Protein

MS4A6E Protein

MS4A2 Protein