concept

CRLF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CRLF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

0Hypotheses

0Analyses

48Outgoing

24Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CRLF2
Key Genes/Proteins	ABL1, ABL2, AND, App, BCL-2, CSF1R
Related Diseases	Als, ALS

Pathway Diagram

graph TD
    CRLF2["CRLF2"]
    CRLF2 -->|"causes"| Ph_Like_ALL["Ph-Like ALL"]
    CRLF2 -->|"activates"| ALS["ALS"]
    CRLF2 -->|"activates"| Leukemia["Leukemia"]
    CRLF2 -->|"inhibits"| Senescence["Senescence"]
    CRLF2 -->|"activates"| Als["Als"]
    CRLF2 -->|"contributes to"| IL7R["IL7R"]
    CRLF2 -->|"contributes to"| PDGFRB["PDGFRB"]
    EPOR["EPOR"] -->|"contributes to"| CRLF2
    PTK2B["PTK2B"] -->|"contributes to"| CRLF2
    GENES["GENES"] -->|"activates"| CRLF2
    IL7R -->|"contributes to"| CRLF2
    ABL1["ABL1"] -->|"contributes to"| CRLF2
    CSF1R["CSF1R"] -->|"contributes to"| CRLF2
    TYK2["TYK2"] -->|"contributes to"| CRLF2
    ETV6["ETV6"] -->|"activates"| CRLF2

Outgoing (48)

Target	Relation	Type	Str
Ph-Like ALL	causes	disease	0.90
PDGFRB	activates	gene	0.70
Senescence	inhibits	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
Leukemia	activates	disease	0.65
Leukemia	inhibits	disease	0.65
ABL2	contributes_to	gene	0.60
ABL1	contributes_to	gene	0.60
EPOR	contributes_to	gene	0.60
PTK2B	contributes_to	gene	0.60
TSLP	contributes_to	gene	0.60
PDGFRB	inhibits	gene	0.60
IL7R	contributes_to	gene	0.60
PDGFRB	contributes_to	gene	0.60
TYK2	contributes_to	gene	0.60
FLT3	contributes_to	gene	0.60
CSF1R	contributes_to	gene	0.60
AND	inhibits	gene	0.60
ABL1	inhibits	gene	0.60
ETV6	activates	gene	0.60
AND	contributes_to	gene	0.60
GENES	activates	gene	0.60
SRC	inhibits	gene	0.60
JAK	inhibits	gene	0.60
MYC	inhibits	gene	0.60
BCL-2	inhibits	gene	0.60
Raf	activates	protein	0.60
Rb	contributes_to	protein	0.60
Pdgf	contributes_to	protein	0.60
Fus	activates	protein	0.60
App	activates	protein	0.60
JAK2	contributes_to	gene	0.60
B Cell	activates	cell_type	0.60
Cytokine	activates	protein	0.60
EPOR	activates	gene	0.60
FLT3	activates	gene	0.60
IL7R	activates	gene	0.60
JAK2	activates	gene	0.60
NTRK3	activates	gene	0.60
PTK2B	activates	gene	0.60
TSLP	activates	gene	0.60
TYK2	activates	gene	0.60
JAK	activates	gene	0.60
CSF1R	activates	gene	0.60
SRC	activates	gene	0.60
Stem Cell	expressed_in	cell_type	0.55
B Cell	expressed_in	cell_type	0.55

Incoming (24)

Source	Relation	Type	Str
EPOR	contributes_to	gene	0.60
PTK2B	contributes_to	gene	0.60
GENES	activates	gene	0.60
IL7R	contributes_to	gene	0.60
ABL1	contributes_to	gene	0.60
CSF1R	contributes_to	gene	0.60
TYK2	contributes_to	gene	0.60
ETV6	activates	gene	0.60
JAK2	contributes_to	gene	0.60
ABL2	contributes_to	gene	0.60
AND	contributes_to	gene	0.60
PDGFRB	contributes_to	gene	0.60
TSLP	contributes_to	gene	0.60
FLT3	contributes_to	gene	0.60
NTRK3	contributes_to	gene	0.60
SRC	inhibits	gene	0.60
MYC	inhibits	gene	0.60
AND	inhibits	gene	0.60
PDGFRB	inhibits	gene	0.60
ABL1	inhibits	gene	0.60
JAK	inhibits	gene	0.60
BCL-2	inhibits	gene	0.60
ABL1	activates	gene	0.60
ABL2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CRLF2 in their description or question text

No additional research found