protein

FLT3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FLT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

0Analyses

39Outgoing

36Incoming

0Experiments

0Debates

Summary

Page for FLT3 Protein

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🔬 Protein Info

Gene Symbol	FLT3
Molecular Weight	143 kDa
Pathways	PI3K, MAPK
GeneCards	FLT3
Human Protein Atlas	FLT3
Extracellular domain	5 immunoglobulin-like domains for ligand binding
Transmembrane helix	Single pass through the membrane
Juxtamembrane domain	Contains regulatory motifs
Kinase domain	Intracellular tyrosine kinase activity
C-terminal tail	Contains tyrosine residues for signaling
Microglia	Primary immune cells of the brain
Neurons	Developmental expression, lower in adults
Neural progenitor cells	During neurogenesis
Endothelial cells	Blood-brain barrier component
Microglial activation	Modulates inflammatory responses
Interactions	ABL1, ABL2, App, ATF6, CP, CR1
KG Connections	71 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FLT3 Protein

protein · 638 words

→

FLT3/FLT3L Cytokine Therapy for Neurodegeneration

therapy · 1616 words

→

Pathway Diagram

graph TD
    FLT3(["FLT3"])
    RAS_pathway_genes["RAS pathway genes"]
    ALS["ALS"]
    Leukemia["Leukemia"]
    Als["Als"]
    NTRK3["NTRK3"]
    CRLF2["CRLF2"]
    CSF1R["CSF1R"]
    ABL2["ABL2"]
    ABL1["ABL1"]
    EPOR["EPOR"]
    PTK2B["PTK2B"]
    TSLP["TSLP"]
    GENES["GENES"]
    IL7R["IL7R"]
    TYK2["TYK2"]
    ETV6["ETV6"]
    RAS_pathway_genes -.-|"associated"| FLT3
    FLT3 -->|"activates"| ALS
    FLT3 -->|"activates"| Leukemia
    FLT3 -->|"activates"| Als
    FLT3 -->|"contributes_to"| NTRK3
    FLT3 -->|"contributes_to"| CRLF2
    FLT3 -->|"contributes_to"| CSF1R
    FLT3 -->|"contributes_to"| ABL2
    FLT3 -->|"contributes_to"| ABL1
    FLT3 -->|"contributes_to"| EPOR
    FLT3 -->|"contributes_to"| PTK2B
    FLT3 -->|"contributes_to"| TSLP
    EPOR -->|"contributes_to"| FLT3
    PTK2B -->|"contributes_to"| FLT3
    GENES -->|"activates"| FLT3
    IL7R -->|"contributes_to"| FLT3
    ABL1 -->|"contributes_to"| FLT3
    CSF1R -->|"contributes_to"| FLT3
    TYK2 -->|"contributes_to"| FLT3
    ETV6 -->|"activates"| FLT3
    style FLT3 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (39)

Target	Relation	Type	Str
MAPK	activates	gene	0.70
Als	activates	disease	0.65
ALS	activates	disease	0.65
Leukemia	activates	disease	0.65
NTRK3	contributes_to	gene	0.60
CRLF2	contributes_to	gene	0.60
ABL2	contributes_to	gene	0.60
ABL1	contributes_to	gene	0.60
EPOR	contributes_to	gene	0.60
PTK2B	contributes_to	gene	0.60
TSLP	contributes_to	gene	0.60
IL7R	activates	gene	0.60
JAK2	activates	gene	0.60
NTRK3	activates	gene	0.60
PDGFRB	activates	gene	0.60
PTK2B	activates	gene	0.60
TYK2	activates	gene	0.60
WT1	associated_with	gene	0.60
NUP98	activates	gene	0.60
epigenetic regulation	participates_in	pathway	0.60
CSF1R	contributes_to	gene	0.60
AND	contributes_to	gene	0.60
JAK2	contributes_to	gene	0.60
GENES	activates	gene	0.60
ETV6	activates	gene	0.60
PDGFRB	contributes_to	gene	0.60
TYK2	contributes_to	gene	0.60
IL7R	contributes_to	gene	0.60
Raf	activates	protein	0.60
Rb	contributes_to	protein	0.60
Pdgf	contributes_to	protein	0.60
Fus	activates	protein	0.60
App	activates	protein	0.60
B Cell	activates	cell_type	0.60
Cytokine	activates	protein	0.60
B Cell	expressed_in	cell_type	0.55
MAPK	associated_with	gene	0.50
TSLP	activates	concept	0.50
EPOR	activates	concept	0.50

Incoming (36)

Source	Relation	Type	Str
RAS pathway genes	associated_with	pathway	0.75
19654408	is a driver of	paper	0.60
19654408	is a target for	paper	0.60
19654408	implicated as driver of	paper	0.60
NTRK3	contributes_to	gene	0.60
CRLF2	contributes_to	gene	0.60
ABL2	activates	gene	0.60
CRLF2	activates	gene	0.60
19654408	driver of	paper	0.60
EPOR	activates	gene	0.60
EPOR	contributes_to	gene	0.60
PTK2B	contributes_to	gene	0.60
GENES	activates	gene	0.60
IL7R	contributes_to	gene	0.60
ABL1	contributes_to	gene	0.60
CSF1R	contributes_to	gene	0.60
TYK2	contributes_to	gene	0.60
ETV6	activates	gene	0.60
JAK2	contributes_to	gene	0.60
ABL2	contributes_to	gene	0.60
PDGFRB	contributes_to	gene	0.60
TSLP	contributes_to	gene	0.60
CR1	interacts_with	gene	0.60
CR1	associated_with	gene	0.60
ATF6	inhibits	gene	0.60
CEBPA	associated_with	gene	0.60
CP	inhibits	gene	0.60
CSF1R	activates	gene	0.50
TYK2	activates	gene	0.50
JAK2	activates	gene	0.50
PDGFRB	activates	gene	0.50
PTK2B	activates	gene	0.50
ABL1	activates	protein	0.50
NTRK3	activates	gene	0.50
IL7R	activates	gene	0.50
LEUKEMIA	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FLT3 in their description or question text

No additional research found