gene

CTSH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTSH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

151Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CTSH is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, activates. Associated with Als, Alzheimer, Amyotrophic Lateral Sclerosis. Connected to 40 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CTSH
Chromosome	15q25.1 [@hook2018]
Protein Type	Protease
Function	is a gene involved in cellular processes relevant to neurodegeneration.
Primary Expression	various tissues:
Molecular Weight	37 kDa
Amino Acids	253 aa
Pathways	signaling:** Regulation of growth factors
UniProt ID	P09668
NCBI Gene ID	1515
Ensembl ID	ENSG00000103852
GeneCards	CTSH
Human Protein Atlas	CTSH
Associated Diseases	Alzheimer, Dementia, Ms
Interactions	Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS
KG Connections	151 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CTSH — AlphaFold P09668 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CTSH Gene

gene · 649 words

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Pathway Diagram

graph TD
    CTSH["CTSH"]
    Als{"Als"}
    CTSH -->|"activates"| Als
    Ms{"Ms"}
    CTSH -->|"activates"| Ms
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    CTSH -->|"activates"| Amyotrophic_Lateral_Sclerosis
    Alzheimer{"Alzheimer"}
    CTSH -->|"associated with"| Alzheimer
    Dementia{"Dementia"}
    CTSH -->|"associated with"| Dementia
    CTSH -->|"associated with"| Ms
    CTSH -->|"therapeutic target"| Alzheimer
    CTSH -->|"therapeutic target"| Ms
    CTSH -->|"therapeutic target"| Dementia
    CTSH -->|"therapeutic target"| Als
    COMPLEMENT["COMPLEMENT"]
    CTSH -->|"interacts with"| COMPLEMENT
    C1QB["C1QB"]
    CTSH -->|"interacts with"| C1QB
    CR2["CR2"]
    CR2 -->|"associated with"| CTSH
    GENETIC_RISK_LOCI["GENETIC RISK LOCI"]
    GENETIC_RISK_LOCI -->|"associated with"| CTSH
    TREM2["TREM2"]
    TREM2 -->|"associated with"| CTSH
    IL6["IL6"]
    IL6 -->|"associated with"| CTSH
    ZCWPW1["ZCWPW1"]
    ZCWPW1 -->|"associated with"| CTSH
    AD_RISK_LOCI["AD RISK LOCI"]
    AD_RISK_LOCI -->|"associated with"| CTSH
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| CTSH
    ALZHEIMER_S_DISEASE -->|"therapeutic target"| CTSH
    style CTSH fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (95)

Target	Relation	Type	Str
Alzheimer's disease	risk_factor_for	disease	0.85
Amyloid-beta protein precursor processing	involved_in	process	0.80
Dementia	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Dementia	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Ms	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
EED	associated_with	gene	0.60
GRN	associated_with	gene	0.60
INPP5D	associated_with	gene	0.60
LILRB2	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
PLCG2	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
PTK2B	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
C1QB	interacts_with	gene	0.60
SOD1	activates	gene	0.60
HSP27	interacts_with	gene	0.60
PILRB	associated_with	gene	0.60
GBA	associated_with	gene	0.60
CR1	associated_with	gene	0.60
SIGLEC9	associated_with	gene	0.60
SIRPA	associated_with	gene	0.60
PHAGOCYTOSIS	associated_with	entity	0.60
AMYLOID	activates	gene	0.60
AND	associated_with	gene	0.60
COMPLEMENT	activates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
Phagocytosis	associated_with	pathway	0.60
Amyloid	activates	pathway	0.60
Complement	activates	pathway	0.60
Actin	activates	protein	0.60
HLA	regulates	gene	0.60
PGRN	regulates	gene	0.60
CTSB	associated_with	gene	0.60
ADAM17	associated_with	gene	0.60
CLU	associated_with	gene	0.60
APP	associated_with	gene	0.60

Incoming (56)

Source	Relation	Type	Str
ALZHEIMER DISEASE	associated_with	gene	0.80
TREM2	associated_with	gene	0.70
ALZHEIMER DISEASE	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
ACE	associated_with	gene	0.60
ABCA1	associated_with	gene	0.60
ABI3	associated_with	gene	0.60
ADAM17	associated_with	gene	0.60
APOE	associated_with	gene	0.60
APP	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
CD33	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CR1	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
CR2	associated_with	gene	0.60
IL6	associated_with	gene	0.60
ZCWPW1	associated_with	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
INPP5D	associated_with	gene	0.60
GRN	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
PTK2B	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
EED	associated_with	gene	0.60
TAU	activates	gene	0.60
GENETIC RISK LOCI	associated_with	gene	0.60
AD RISK LOCI	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
COMPLEMENT	activates	gene	0.60
LILRB2	associated_with	gene	0.60
LRP1	activates	gene	0.60
SIGLEC9	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
CLN5	associated_with	gene	0.60
CLN5	interacts_with	gene	0.60
ABCA1	regulates	gene	0.60
APOE	regulates	gene	0.60
CTSB	regulates	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
APOE	co_discussed	gene	0.50
APP	co_discussed	gene	0.50
BIN1	co_discussed	gene	0.50
CD2AP	co_discussed	protein	0.50
CLU	co_discussed	gene	0.50
CR1	co_discussed	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CTSH in their description or question text

No additional research found