concept

TSLP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TSLP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

138Connections

0Hypotheses

0Analyses

50Outgoing

48Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TSLP
Key Genes/Proteins	ABL1, ABL2, Actin, AHR, AKT, AND
Related Diseases	Aging, Als, ALS, Asthma, Cancer
Related Pathways	Autophagy

Wiki Pages (1)

Knowledge base pages for this entity

TSLP Signaling in Neuroinflammation

mechanism · 973 words

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Pathway Diagram

graph TD
    TSLP["TSLP"]
    TSLP -.protects against.-> Epigenetic["Epigenetic"]
    TSLP -->|"regulates"| Als["Als"]
    TSLP -->|"activates"| Inflammation["Inflammation"]
    TSLP -->|"activates"| ALS["ALS"]
    TSLP -->|"activates"| Leukemia["Leukemia"]
    TSLP -->|"regulates"| Asthma["Asthma"]
    TSLP -->|"regulates"| Pneumonia["Pneumonia"]
    TSLP -->|"activates"| Psoriasis["Psoriasis"]
    ABL1["ABL1"] -->|"contributes to"| TSLP
    CSF1R["CSF1R"] -->|"contributes to"| TSLP
    EPOR["EPOR"] -->|"contributes to"| TSLP
    TYK2["TYK2"] -->|"contributes to"| TSLP
    NTRK3["NTRK3"] -->|"contributes to"| TSLP
    IL7R["IL7R"] -->|"contributes to"| TSLP
    ETV6["ETV6"] -->|"activates"| TSLP
    GENES["GENES"] -->|"activates"| TSLP
    PDGFRB["PDGFRB"] -->|"contributes to"| TSLP
    PTK2B["PTK2B"] -->|"contributes to"| TSLP

Outgoing (90)

Target	Relation	Type	Str
Inflammation	activates	disease	0.75
Als	regulates	disease	0.75
Als	inhibits	disease	0.65
Psoriasis	activates	disease	0.65
Asthma	regulates	disease	0.65
Asthma	activates	disease	0.65
Asthma	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Pneumonia	regulates	disease	0.65
Inflammation	regulates	disease	0.65
ALS	activates	disease	0.65
ALS	associated_with	disease	0.65
Leukemia	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Inflammation	implicated_in	disease	0.65
INFLAMMATION	regulates	gene	0.60
MYD88	regulates	gene	0.60
IFN	associated_with	gene	0.60
Nf-Κb	regulates	pathway	0.60
Nf-Kb	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
CANCER	regulates	gene	0.60
Immune Response	therapeutic_target	pathway	0.60
MITOPHAGY	regulates	gene	0.60
INFLAMMATION	implicated_in	gene	0.60
NLRX1	regulates	gene	0.60
PARKIN	regulates	gene	0.60
Mitophagy	regulates	pathway	0.60
INFLAMMATION	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
OPTN	activates	gene	0.60
Autophagy	activates	pathway	0.60
FLT3	contributes_to	gene	0.60
CRLF2	contributes_to	gene	0.60
Epithelial	contributes_to	cell_type	0.60
T Cell	activates	cell_type	0.60
Oxidative Stress	interacts_with	pathway	0.60
IL-33	inhibits	gene	0.60
CYTOKINES	associated_with	gene	0.60
JAK2	contributes_to	gene	0.60
NTRK3	contributes_to	gene	0.60
ABL2	contributes_to	gene	0.60
TYK2	contributes_to	gene	0.60
PTK2B	contributes_to	gene	0.60
PDGFRB	contributes_to	gene	0.60
ETV6	activates	gene	0.60
IL7R	contributes_to	gene	0.60

Incoming (48)

Source	Relation	Type	Str
AND	associated_with	gene	0.60
CSF1R	contributes_to	gene	0.60
EPOR	contributes_to	gene	0.60
TYK2	contributes_to	gene	0.60
NTRK3	contributes_to	gene	0.60
IL7R	contributes_to	gene	0.60
ETV6	activates	gene	0.60
GENES	activates	gene	0.60
PDGFRB	contributes_to	gene	0.60
PTK2B	contributes_to	gene	0.60
JAK2	contributes_to	gene	0.60
INFLAMMATION	activates	gene	0.60
TNF-Α	associated_with	gene	0.60
TNF	associated_with	gene	0.60
PINK1	regulates	gene	0.60
ABL2	contributes_to	gene	0.60
CRLF2	contributes_to	gene	0.60
FLT3	contributes_to	gene	0.60
CYTOKINES	inhibits	gene	0.60
IL-33	therapeutic_target	gene	0.60
CYTOKINES	interacts_with	gene	0.60
CRH	associated_with	gene	0.60
IL-33	associated_with	gene	0.60
INFLAMMATION	inhibits	gene	0.60
OXIDATIVE STRESS	interacts_with	gene	0.60
IL-1	inhibits	gene	0.60
CXCL8	inhibits	gene	0.60
CHI3L1	inhibits	gene	0.60
IL-4	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
ABL2	activates	gene	0.60
CRLF2	activates	gene	0.60
ABL1	contributes_to	gene	0.60
FLT3	activates	protein	0.50
EPOR	activates	concept	0.50
Asthma	inhibits	disease	0.50
COPD	inhibits	disease	0.50
disease	associated_with	disease	0.50
Asthma	associated_with	disease	0.50
COPD	associated_with	disease	0.50
PDGFRB	activates	gene	0.50
IL7R	activates	gene	0.50
CSF1R	activates	gene	0.50
TYK2	activates	gene	0.50
JAK2	activates	gene	0.50
NTRK3	activates	gene	0.50
PTK2B	activates	gene	0.50
ABL1	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TSLP in their description or question text

No additional research found