gene

CD33

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD33: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

657Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

A gene referenced in 1 knowledge graph relationship. Key connections: inhibits phagocytosis (mechanism).

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🧬 Gene Info

Gene Symbol	CD33
Full Name	Cluster of Differentiation 33
Aliases	Siglec-3
Chromosome	19q13.41
Function	Sialic acid binding: Recognizes α2,6-linked sialic acids on glycoproteins
Molecular Weight	67 kDa
Amino Acids	354 aa
Exons	7
Pathways	Apoptosis, Autophagy, Blood-Brain Barrier, Dysbiosis, Epigenetic
UniProt ID	[P20138](https://www.uniprot.org/uniprot/P20138)
GeneCards	CD33
Human Protein Atlas	CD33
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	Stem Cell Therapy
Interactions	ABCA7, Actin, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID
KG Connections	657 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CD33["CD33"]
    CD33 -->|"interacts"| Als["Als"]
    CD33 -->|"interacts"| Tauopathy["Tauopathy"]
    CD33 -->|"inhibits"| Leukemia["Leukemia"]
    CD33 -->|"inhibits"| Ms["Ms"]
    CD33 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    CD33 -->|"target for"| Alzheimer["Alzheimer"]
    CD33 -->|"target for"| Neuroinflammation["Neuroinflammation"]
    CD33 -->|"target for"| Inflammation["Inflammation"]
    TYROBP["TYROBP"] -->|"interacts"| CD33
    APP["APP"] -->|"interacts"| CD33
    PSEN1["PSEN1"] -->|"interacts"| CD33
    BCL2["BCL2"] -->|"inhibits"| CD33
    MICROGLIA["MICROGLIA"] -->|"interacts"| CD33
    NEURODEGENERATION["NEURODEGENERATION"] -->|"target for"| CD33
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| CD33

Outgoing (478)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CD33	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Alzheimer Disease	risk_factor_for	disease	0.90
microglia	associated_with	cell_type	0.90
T cells	expressed_in	cell_type	0.90
Microglial Phagocytosis of Amyloid-β	involved_in	process	0.85
Alzheimer's Disease	risk_factor_for	disease	0.85
Amyloid Pathology	involved_in	process	0.85
Amyloid-Beta Clearance	regulates	process	0.85
Microglial Activation	regulates	process	0.85
Microglial Function	modulates	process	0.85
microglial activation	regulates	process	0.80
macrophages	expressed_in	cell_type	0.80
Alzheimer's disease	biomarker_for	disease	0.80
oxidative stress response	participates_in	pathway	0.80
Aβ pathology	inhibits	disease	0.80
neuroinflammation	activates	disease	0.80
Als	activates	disease	0.75
amyloid-beta clearance	modulates	process	0.75
Als	therapeutic_target	disease	0.75
Alzheimer	associated_with	disease	0.75
Leukemia	therapeutic_target	disease	0.75
Alzheimer	regulates	disease	0.75
ALZHEIMER'S DISEASE	associated_with	gene	0.70
stem cells	expressed_in	cell_type	0.70
MICROGLIA	associated_with	gene	0.70
phagocytosis	activates	process	0.70
Parkinson's disease	causes	disease	0.70
Alzheimer's disease	causes	disease	0.70
TREM2	associated_with	gene	0.70
Alzheimer's disease	interacts_with	disease	0.70
TREM2	inhibits	protein	0.70
HLA	regulates	gene	0.70
PSEN2	regulates	gene	0.70
GPNMB	causes	gene	0.70
ALZHEIMER	regulates	gene	0.70
CLU	regulates	gene	0.70
neuroinflammation	associated_with	disease	0.70
ALZHEIMER	associated_with	gene	0.70
ALS	interacts_with	disease	0.65
PHAGOCYTOSIS	associated_with	phenotype	0.65
PARKINSON	associated_with	gene	0.65
Tumor	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
DEMENTIA	associated_with	gene	0.65
NEURODEGENERATION	associated_with	concept	0.65
Ms	therapeutic_target	disease	0.65
Tauopathy	activates	disease	0.65
NEUROINFLAMMATION	associated_with	concept	0.65
Als	associated_with	disease	0.65

Incoming (179)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CD33	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
AMYLOID	associated_with	gene	0.90
APOE	associated_with	gene	0.90
MICROGLIA	associated_with	cell_type	0.82
TREM2	associated_with	gene	0.82
ALZHEIMER DISEASE	associated_with	gene	0.80
Stem Cell Therapy	modulates	drug	0.80
NEURODEGENERATION	protects_against	phenotype	0.70
NEURODEGENERATION	associated_with	gene	0.66
TREM2	regulates	gene	0.66
APP	associated_with	gene	0.66
ALS	associated_with	gene	0.65
PHAGOCYTOSIS	causes	phenotype	0.65
PHAGOCYTOSIS	degrades	phenotype	0.65
MICROGLIA	targets	cell_type	0.65
AMYLOID-BETA	causes	protein	0.65
BDNF	co_discussed	gene	0.65
APP	treats	gene	0.65
T CELLS	produces	cell_type	0.65
TYROBP	interacts_with	protein	0.64
APP	activates	gene	0.60
BCL2	inhibits	gene	0.60
ABCA7	activates	gene	0.60
IBA1	inhibits	gene	0.60
PSEN2	regulates	gene	0.60
TAU	regulates	gene	0.60
DAP12	interacts_with	gene	0.60
SORL1	regulates	gene	0.60
CD47	associated_with	gene	0.60
APP	interacts_with	gene	0.60
APP	inhibits	gene	0.60
GRN	associated_with	gene	0.60
ZCWPW1	activates	gene	0.60
CELF1	activates	gene	0.60
CASS4	activates	gene	0.60
CTSB	associated_with	gene	0.60
PSEN1	interacts_with	gene	0.60
APOE	inhibits	gene	0.60
HuM195	binds_to	protein	0.60
CASS4	associated_with	gene	0.60
sialic acid glycans	binds_to	molecule	0.60
TAU	activates	gene	0.60
GAIN	activates	gene	0.60
NEURODEGENERATION	targets	gene	0.60
CR1	associated_with	gene	0.60
STAT3	activates	gene	0.60
MMP12	regulates	gene	0.60
PICALM	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.591

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.914

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

The abstract shows TYROBP deficiency is neuroprotective despite being required f

closed · Rounds: 4 · Score: 0.56 · 2026-04-15

Investigate prion-like spreading of tau pathology through connected brain region

closed · Rounds: 4 · Score: 0.90 · 2026-04-12

Epigenetic reprogramming in aging neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Tau propagation mechanisms and therapeutic interception points

closed · Rounds: 3 · Score: 0.95 · 2026-04-04

Related Research

Hypotheses and analyses mentioning CD33 in their description or question text

No additional research found

CD33

Understanding Entity Pages

Summary

Wiki Pages (8)

CD33 — Cluster of Differentiation 33

Neuroimmune Genes in Alzheimer's Disease — TREM2, CD33, PLD3

SIGLEC3 Gene (CD33)

CD33 Protein — Cluster of Differentiation 33 (Siglec-3)

CD33 Siglec Receptor Dysfunction Alzheimer's Disease Causal Chain

CD33 Modulation Therapy for Neurodegeneration

CD33 (Siglec-3)

CD33-Positive Microglia

Pathway Diagram

Outgoing (478)

Incoming (179)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

Epigenetic reprogramming in aging neurons

Tau propagation mechanisms and therapeutic interception points

Experiments (0)

Related Papers (0)

Debates (4)

The abstract shows TYROBP deficiency is neuroprotective despite being required f

Investigate prion-like spreading of tau pathology through connected brain region

Epigenetic reprogramming in aging neurons

Tau propagation mechanisms and therapeutic interception points

Related Research