concept

SIGLEC11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIGLEC11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

0Hypotheses

0Analyses

14Outgoing

33Incoming

0Experiments

0Debates

No summary available yet. View on Wiki →

No AI portrait yet

💡 Concept Info

Name	SIGLEC11
Key Genes/Proteins	ABCA1, ABI3, ACE, ADAM17, ADRA2A, ALZHEIMER DISEASE
Related Diseases	Alzheimer's disease, autism spectrum disorder

Pathway Diagram

graph TD
    SIGLEC11[SIGLEC11]
    SIGLEC11 -->|regulates| Immune_Cell_Distribution[Immune Cell Distribution]
    SIGLEC11 -->|implicated in| SORL1[SORL1]
    SIGLEC11 -->|implicated in| SPI1[SPI1]
    SIGLEC11 -->|implicated in| TMEM106B[TMEM106B]
    SIGLEC11 -->|implicated in| TREM2[TREM2]
    SIGLEC11 -->|interacts| schizophrenia[schizophrenia]
    SIGLEC11 -->|interacts| neurodegeneration[neurodegeneration]
    SIGLEC11 -->|interacts| Alzheimer_s_disease[Alzheimer's disease]
    SIGLEC11 -->|interacts| autism_spectrum_disorder[autism spectrum disorder]
    SIGLEC11 -->|expressed in| microglia[microglia]
    ABCA1[ABCA1] -->|implicated in| SIGLEC11
    ABI3[ABI3] -->|implicated in| SIGLEC11
    ACE[ACE] -->|implicated in| SIGLEC11
    ADAM17[ADAM17] -->|implicated in| SIGLEC11
    APOE[APOE] -->|implicated in| SIGLEC11
    APP[APP] -->|implicated in| SIGLEC11
    BIN1[BIN1] -->|implicated in| SIGLEC11
    CD2AP[CD2AP] -->|implicated in| SIGLEC11
    CD33[CD33] -->|implicated in| SIGLEC11
    CLU[CLU] -->|implicated in| SIGLEC11

Outgoing (14)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:SIGLEC11	data_in	dataset_row	0.00
Immune Cell Distribution	regulates	process	0.78
SORL1	implicated_in	gene	0.60
SPI1	implicated_in	gene	0.60
TMEM106B	implicated_in	gene	0.60
TREM2	implicated_in	gene	0.60
SLC24A4	associated_with	gene	0.60
SPINT1	associated_with	gene	0.60
XPR1	associated_with	gene	0.60
Alzheimer's disease	interacts_with	disease	0.60
autism spectrum disorder	interacts_with	disease	0.60
schizophrenia	interacts_with	disease	0.60
neurodegeneration	interacts_with	disease	0.60
microglia	expressed_in	cell_type	0.55

Incoming (33)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:SIGLEC11	data_in	dataset_row	0.00
ALZHEIMER DISEASE	associated_with	gene	0.80
ABI3	implicated_in	gene	0.60
ACE	implicated_in	gene	0.60
ADAM17	implicated_in	gene	0.60
APOE	implicated_in	gene	0.60
APP	implicated_in	gene	0.60
BIN1	implicated_in	gene	0.60
CD2AP	implicated_in	gene	0.60
CD33	implicated_in	gene	0.60
CLU	implicated_in	gene	0.60
CR1	implicated_in	gene	0.60
CTSB	implicated_in	gene	0.60
CTSH	implicated_in	gene	0.60
EED	implicated_in	gene	0.60
GRN	implicated_in	gene	0.60
INPP5D	implicated_in	gene	0.60
LILRB2	implicated_in	gene	0.60
PICALM	implicated_in	gene	0.60
PLCG2	implicated_in	gene	0.60
PSEN1	implicated_in	gene	0.60
PTK2B	implicated_in	gene	0.60
ADRA2A	associated_with	gene	0.60
CD36	associated_with	gene	0.60
MAP1A	associated_with	gene	0.60
GRAMD1B	associated_with	gene	0.60
NFE2L3	associated_with	gene	0.60
ABCA1	implicated_in	gene	0.60
CD33	interacts_with	gene	0.60
MAG	interacts_with	gene	0.60
CDC42EP3	associated_with	gene	0.60
FGFRL1	associated_with	gene	0.60
MYL9	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity