concept

EPOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

122Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

EPOR is a concept in neurodegeneration research. Key relationships include: regulates, contributes to, activates. Associated with ALS, Als, Leukemia. Connected to 70 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	EPOR
Key Genes/Proteins	ABL1, ABL2, AKT, App, BCL-2, CRLF2
Related Diseases	Als, ALS
Related Pathways	Akt

Pathway Diagram

graph TD
    EPOR["EPOR"]
    EPOR -->|"regulates"| Als["Als"]
    EPOR -->|"activates"| Leukemia["Leukemia"]
    EPOR -->|"regulates"| ALS["ALS"]
    EPOR -->|"regulates"| TLR4["TLR4"]
    EPOR -->|"regulates"| FGF8["FGF8"]
    EPOR -->|"regulates"| CSF2["CSF2"]
    EPOR -->|"regulates"| AKT["AKT"]
    EPOR -->|"regulates"| ISG15["ISG15"]
    ruxolitinib["ruxolitinib"] -->|"inhibits"| EPOR
    HSPA1A["HSPA1A"] -->|"regulates"| EPOR
    P38["P38"] -->|"regulates"| EPOR
    CXCL10["CXCL10"] -->|"regulates"| EPOR
    ERK["ERK"] -->|"regulates"| EPOR
    FGF2["FGF2"] -->|"regulates"| EPOR
    PI3K["PI3K"] -->|"regulates"| EPOR
    STAT1["STAT1"] -->|"regulates"| EPOR
    NAMPT["NAMPT"] -->|"regulates"| EPOR
    S100A8["S100A8"] -->|"regulates"| EPOR

Outgoing (70)

Target	Relation	Type	Str
Als	activates	disease	0.65
Leukemia	activates	disease	0.65
ALS	regulates	disease	0.65
ALS	activates	disease	0.65
Als	regulates	disease	0.65
FGF8	regulates	gene	0.60
CSF2	regulates	gene	0.60
AKT	regulates	gene	0.60
ISG15	regulates	gene	0.60
CSF2RA	regulates	gene	0.60
Akt	regulates	pathway	0.60
Pi3K	regulates	pathway	0.60
Mapk	regulates	pathway	0.60
CXCL10	regulates	gene	0.60
EPO	regulates	gene	0.60
S100A8	regulates	gene	0.60
P38	regulates	gene	0.60
ERK	regulates	gene	0.60
NAMPT	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
STAT1	regulates	gene	0.60
BCL-2	regulates	gene	0.60
TLR4	regulates	gene	0.60
ABL1	contributes_to	gene	0.60
Neutrophil	regulates	cell_type	0.60
Interferon	regulates	protein	0.60
Cytokine	regulates	protein	0.60
B Cell	activates	cell_type	0.60
Cytokine	activates	protein	0.60
Rb	regulates	protein	0.60
Fgf	regulates	protein	0.60
Ubiquitin	regulates	protein	0.60
CSF1R	contributes_to	gene	0.60
TYK2	contributes_to	gene	0.60
IL7R	contributes_to	gene	0.60
LGALS9	regulates	gene	0.60
GENES	regulates	gene	0.60
FGF2	regulates	gene	0.60
PI3K	regulates	gene	0.60
Pi3K/Akt	regulates	pathway	0.60
FLT3	contributes_to	gene	0.60
CRLF2	contributes_to	gene	0.60
Rb	contributes_to	protein	0.60
Pdgf	contributes_to	protein	0.60
Fus	expressed_in	protein	0.60
App	activates	protein	0.60
FLT3	activates	gene	0.60
IL7R	activates	gene	0.60
JAK2	activates	gene	0.60
NTRK3	activates	gene	0.60

Incoming (52)

Source	Relation	Type	Str
ruxolitinib	inhibits	drug	0.64
AKT	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
P38	regulates	gene	0.60
CXCL10	regulates	gene	0.60
ERK	regulates	gene	0.60
FGF2	regulates	gene	0.60
PI3K	regulates	gene	0.60
STAT1	regulates	gene	0.60
NAMPT	regulates	gene	0.60
S100A8	regulates	gene	0.60
GENES	regulates	gene	0.60
BCL-2	regulates	gene	0.60
CSF2	regulates	gene	0.60
FGF8	regulates	gene	0.60
EPO	regulates	gene	0.60
TSLP	contributes_to	gene	0.60
ABL2	contributes_to	gene	0.60
NTRK3	contributes_to	gene	0.60
PTK2B	contributes_to	gene	0.60
ETV6	expressed_in	gene	0.60
ABL1	contributes_to	gene	0.60
PDGFRB	contributes_to	gene	0.60
GENES	activates	gene	0.60
JAK2	contributes_to	gene	0.60
CSF1R	contributes_to	gene	0.60
LGALS9	regulates	gene	0.60
ABL2	activates	gene	0.60
CRLF2	activates	gene	0.60
ABL2	expressed_in	gene	0.60
dasatinib	targets	drug	0.60
TLR4	regulates	gene	0.60
ISG15	regulates	gene	0.60
CSF2RA	regulates	gene	0.60
TYK2	contributes_to	gene	0.60
CRLF2	contributes_to	gene	0.60
IL7R	contributes_to	gene	0.60
FLT3	contributes_to	gene	0.60
PDGFRB	activates	gene	0.50
IL7R	activates	gene	0.50
CSF1R	activates	gene	0.50
TYK2	activates	gene	0.50
JAK2	activates	gene	0.50
NTRK3	activates	gene	0.50
PTK2B	activates	gene	0.50
ABL1	activates	protein	0.50
FLT3	activates	protein	0.50
PDGFRB	expressed_in	gene	0.50
CSF1R	expressed_in	gene	0.50
JAK2	expressed_in	gene	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Rab12 may better report chronic lysosomal stress biology tha	0.670	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo
A genetically encoded reporter for axonal mitochondrial prot	0.565	neuroscience	How can subcellular compartmentalization

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EPOR in their description or question text

No additional research found