gene

PLCG2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLCG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

345Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

1Experiments

3Debates

Summary

A gene referenced in 1 knowledge graph relationship. Key connections: encodes PLCgamma2 (protein).

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🧬 Gene Info

Gene Symbol	PLCG2
Full Name	Phospholipase C Gamma 2
Chromosome	16q23.3
Protein Type	Enzyme
Primary Expression	hematopoietic cells and microglia
Molecular Weight	150 kDa
Amino Acids	265 aa
Pathways	MAPK
UniProt ID	P16885
NCBI Gene ID	5336
Ensembl ID	ENSG00000197943
OMIM	600220
GeneCards	PLCG2
Human Protein Atlas	PLCG2
Associated Diseases	AD, AD risk, Aging, Als, Alzheimer, Alzheimer's disease
Interactions	Actin, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID, Amyloid Beta
SciDEX Hypotheses	PLCG2 Allosteric Modulation as a Precision Therape
KG Connections	345 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PLCG2 — AlphaFold P16885 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PLCG2["PLCG2"]
    Cancer{"Cancer"}
    PLCG2 -->|"activates"| Cancer
    Carcinoma{"Carcinoma"}
    PLCG2 -->|"activates"| Carcinoma
    Ms{"Ms"}
    PLCG2 -->|"activates"| Ms
    PLCG2 -->|"inhibits"| Cancer
    PLCG2 -->|"inhibits"| Carcinoma
    Alzheimer{"Alzheimer"}
    PLCG2 -->|"associated with"| Alzheimer
    PLCG2 -->|"associated with"| Ms
    PLCG2 -->|"regulates"| Alzheimer
    Als{"Als"}
    PLCG2 -->|"associated with"| Als
    ABCB1["ABCB1"]
    PLCG2 -->|"contributes to"| ABCB1
    PARP1["PARP1"]
    PLCG2 -->|"contributes to"| PARP1
    DOT1L["DOT1L"]
    PLCG2 -->|"contributes to"| DOT1L
    DOT1L -->|"contributes to"| PLCG2
    ABCB1 -->|"contributes to"| PLCG2
    PARP1 -->|"contributes to"| PLCG2
    TREM2["TREM2"]
    TREM2 -->|"associated with"| PLCG2
    ABI3["ABI3"]
    ABI3 -->|"regulates"| PLCG2
    TREM2 -->|"regulates"| PLCG2
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| PLCG2
    AND["AND"]
    AND -->|"regulates"| PLCG2
    APP["APP"]
    APP -->|"associated with"| PLCG2
    ALZHEIMER_S_DISEASE -->|"associated with"| PLCG2
    NDUFAF7["NDUFAF7"]
    NDUFAF7 -->|"associated with"| PLCG2
    SHARPIN["SHARPIN"]
    SHARPIN -->|"associated with"| PLCG2
    style PLCG2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (226)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PLCG2	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ds-f50762b67605	provides_data_for	dataset	1.00
ds-db4a006ea647	provides_data_for	dataset	1.00
MICROGLIA	expressed_in	cell_type	0.90
AD risk	associated_with	disease	0.90
Cognitive Resilience	associated_with	phenotype	0.88
NEUROINFLAMMATION	mediates	process	0.85
amyloid beta plaques	mediates	process	0.80
microglia	expressed_in	cell_type	0.80
neuroinflammation	modulates	process	0.80
microglial phenotype	modulates	mechanism	0.70
Alzheimer	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Alzheimer	regulates	disease	0.65
Carcinoma	inhibits	disease	0.65
Parkinson	biomarker_for	disease	0.65
Cancer	inhibits	disease	0.65
Anxiety	protects_against	disease	0.65
Als	associated_with	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
PHAGOCYTOSIS	associated_with	phenotype	0.65
Frontotemporal Dementia	activates	disease	0.65
TAU	regulates	protein	0.65
TAU	inhibits	protein	0.65
Alzheimer	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Diabetes	protects_against	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Dementia	activates	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
MACROPHAGE	regulates	cell_type	0.65
Multiple Sclerosis	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Cancer	activates	disease	0.65
Carcinoma	activates	disease	0.65
Ms	activates	disease	0.65
PHAGOCYTOSIS	interacts_with	phenotype	0.65
PHAGOCYTOSIS	inhibits	phenotype	0.65
NEUROINFLAMMATION	regulates	phenotype	0.65
T CELLS	activates	cell_type	0.65
CHRNE	associated_with	gene	0.60
PTK2B	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
SPI1	associated_with	gene	0.60

Incoming (119)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PLCG2	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
ds-f50762b67605	data_in	dataset	1.00
ds-db4a006ea647	data_in	dataset	1.00
h-d2937ed0	targets	hypothesis	0.90
ALZHEIMER'S DISEASE	associated_with	gene	0.82
NF-ΚB1	upregulates	gene	0.80
ALZHEIMER DISEASE	associated_with	gene	0.80
APOE	associated_with	gene	0.74
ALZHEIMER'S DISEASE	encodes	disease	0.65
ABCB1	associated_with	gene	0.60
DOT1L	associated_with	gene	0.60
PARP1	associated_with	gene	0.60
ABCA1	associated_with	gene	0.60
ACE	associated_with	gene	0.60
ADAM17	associated_with	gene	0.60
APP	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
CD33	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CR1	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
CTSH	associated_with	gene	0.60
EED	associated_with	gene	0.60
GRN	associated_with	gene	0.60
INPP5D	associated_with	gene	0.60
LILRB2	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
RNA	therapeutic_target	gene	0.60
ABI3	associated_with	gene	0.60
ABCB1	regulates	entity	0.60
DOT1L	regulates	entity	0.60
PTK2B	associated_with	gene	0.60
PHAGOCYTOSIS	associated_with	entity	0.60
DEMENTIA	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
ALZHEIMER	regulates	gene	0.60
SHARPIN	associated_with	gene	0.60
LRP1	activates	gene	0.60
SPI1	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
TAU	activates	gene	0.60
NRF2	biomarker_for	gene	0.60
GENES	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PLCG2 Allosteric Modulation as a Precision Therapeutic for T	0.941	neurodegeneration	TREM2 agonism vs antagonism in DAM micro

Mentioning Analyses (2)

Scientific analyses that reference this entity

Clinical Trial Landscaping for Alzheimer's Disease Therapeutics

neurodegeneration | 2026-04-16 | 0 hypotheses

TREM2 agonism vs antagonism in DAM microglia

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.941

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
E2F coordination of G2/M transcriptional program	exploratory		0.750	0.00	endocycling mammalian cells	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

What is the current clinical trial landscape for AD therapeutics, and which mech

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Is the amyloid concentration in AD clinical trials rational given lecanemab's ap

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

The disease-associated microglia (DAM) phenotype involves TREM2 upregulation, bu

closed · Rounds: 4 · Score: 0.57 · 2026-04-01

Related Research

Hypotheses and analyses mentioning PLCG2 in their description or question text

No additional research found