concept

GLUTAMATE SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLUTAMATE SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

254Connections

0Hypotheses

1Analyses

30Outgoing

50Incoming

0Experiments

1Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	GLUTAMATE SIGNALING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Glutamate Signaling Pathway

mechanism · 1212 words

→

Pathway Diagram

graph TD
    GLUTAMATE_SIGNALING["GLUTAMATE SIGNALING"]
    Als["Als"] -->|"activates"| GLUTAMATE_SIGNALING
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| GLUTAMATE_SIGNALING
    NEURODEGENERATION["NEURODEGENERATION"] -->|"target for"| GLUTAMATE_SIGNALING
    Neurodegeneration["Neurodegeneration"] -->|"target for"| GLUTAMATE_SIGNALING
    GPX4["GPX4"] -->|"activates"| GLUTAMATE_SIGNALING
    GENES["GENES"] -->|"activates"| GLUTAMATE_SIGNALING
    INFLAMMATION["INFLAMMATION"] -->|"regulates"| GLUTAMATE_SIGNALING

Outgoing (30)

Target	Relation	Type	Str
Temporal Lobe Epilepsy	involved_in	disease	0.95
neurons	active_in	cell_type	0.90
hippocampus	active_in	brain_region	0.90
blood-brain barrier	active_in	brain_region	0.70
synaptic plasticity	crosstalk_with	pathway	0.70
cortex	active_in	brain_region	0.70
neural stem cells	active_in	cell_type	0.70
unfolded protein response	crosstalk_with	pathway	0.70
astrocytes	active_in	cell_type	0.70
macrophages	active_in	cell_type	0.60
endothelial cells	active_in	cell_type	0.60
white matter	active_in	brain_region	0.60
spinal cord	active_in	brain_region	0.60
interneurons	active_in	cell_type	0.60
protein misfolding	mediates	process	0.60
hypothalamus	active_in	brain_region	0.60
necroptosis	crosstalk_with	pathway	0.60
pyroptosis	crosstalk_with	pathway	0.60
GABAergic neurons	active_in	cell_type	0.60
thalamus	active_in	brain_region	0.60
oligodendrocytes	active_in	cell_type	0.60
microglia	active_in	cell_type	0.60
B cells	active_in	cell_type	0.60
Neuron	encodes	cell_type	0.50
Interneuron	encodes	cell_type	0.50
DOPAMINE	regulates	concept	0.50
Neuron	regulates	cell_type	0.50
Interneuron	regulates	cell_type	0.50
Stem Cell	activates	cell_type	0.50
Neuron	activates	cell_type	0.50

Incoming (224)

Source	Relation	Type	Str
Alzheimer's disease	involves	disease	0.90
neurodegeneration	involves	disease	0.90
NMDA receptor	activates	receptor	0.90
PSD-95	participates_in	gene	0.85
NMDA	participates_in	gene	0.85
neurons	active_in	cell_type	0.85
neuroinflammation	involves	disease	0.80
memantine	modulates	compound	0.80
glutamate receptor	activates	receptor	0.80
ALS	participates_in	gene	0.80
ALS	involves	disease	0.80
epilepsy	involves	disease	0.80
APP	participates_in	gene	0.80
Als	activates	disease	0.80
astrocytes	active_in	cell_type	0.75
APC	participates_in	gene	0.70
NEURODEGENERATION	activates	gene	0.70
Neurodegeneration	therapeutic_target	disease	0.70
NEURODEGENERATION	therapeutic_target	gene	0.70
Neurodegeneration	activates	disease	0.70
spinal muscular atrophy	involves	disease	0.70
FERROPTOSIS	activates	gene	0.70
CDK5	regulates	gene	0.70
AMPA receptor	activates	receptor	0.70
PSD95	participates_in	gene	0.65
GFAP	activates	gene	0.60
CCL2	participates_in	gene	0.60
TGF	participates_in	gene	0.60
STIM1	participates_in	gene	0.60
JUN	activates	gene	0.60
BAX	activates	gene	0.60
C-JUN	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
JNK	activates	gene	0.60
Neuroinflammation	activates	disease	0.60
Inflammation	activates	disease	0.60
EPILEPSY	activates	gene	0.60
SST	associated_with	gene	0.60
PVALB	associated_with	gene	0.60
SLC7A11	therapeutic_target	gene	0.60
ROS	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
Tumor	therapeutic_target	disease	0.60
Glioma	associated_with	disease	0.60
Cancer	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract claims Cdk5 activation is the primary cause of AD, contradicting th

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

Related Research

Hypotheses and analyses mentioning GLUTAMATE SIGNALING in their description or question text

No additional research found