gene 2,370 words KG: PTK2B
Contents

PTK2B — Protein Tyrosine Kinase 2 Beta (Pyk2)

🧬 Gene Info
Gene SymbolPTK2B
Full NameProtein Tyrosine Kinase 2 Beta (Pyk2)
Chromosome8p21.1
Protein TypeReceptor
Functionis a non-receptor tyrosine kinase that belongs to the focal adhesion kinase (FAK) family.
Primary ExpressionNeurons, Microglia, Astrocytes
Molecular Weight115 kDa
Amino Acids1009 aa
Exons34
PathwaysAdaptive Immunity, Amyloid, Complement, glutamate signaling
UniProt IDQ14289
NCBI Gene ID5793
Ensembl IDENSG00000163599
OMIM607350
GeneCardsPTK2B
Human Protein AtlasPTK2B
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, disease
InteractionsABCA7, ABL1, ABL2, Actin, ALZHEIMER, ALZHEIMER DISEASE
KG Connections385 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (12)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76

Related Analyses (3)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

ABCA7 (Redirect)
redirect · KG edge: activates
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with
adam17
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TYK2 contributes_to PTK2B
PTK2B contributes_to IL7R
PTK2B contributes_to JAK2
PTK2B contributes_to PDGFRB
PTK2B contributes_to NTRK3
PTK2B contributes_to CSF1R
NTRK3 contributes_to PTK2B
PTK2B contributes_to TYK2
PIK3CA associated_with PTK2B
PTK2B therapeutic_target GATA2

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