gene

EED

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EED: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

127Connections

30Hypotheses

0Analyses

50Outgoing

50Incoming

11Experiments

0Debates

Summary

EED is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, interacts with. Associated with Als, Cancer, Inflammation. Connected to 23 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	EED
Full Name	Embryonic Ectoderm Development
Chromosome	11q14.2
Function	encodes a core scaffolding subunit of Polycomb Repressive Complex 2 (PRC2), the multisubunit complex responsible for trimethylation of histone H3 at lysine 27 (H3K27me3).
Pathways	Mapk, Microrna, Nf-Kb, Wnt
UniProt ID	O75530
Ensembl ID	ENSG00000074266
OMIM	605984
GeneCards	EED
Human Protein Atlas	EED
Associated Diseases	neurodegeneration
Interactions	Actin, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, Aβ, COMPLEMENT
KG Connections	127 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: EED — AlphaFold O75530 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

EED

gene · 1034 words

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Pathway Diagram

graph TD
    EED["EED (gene)"]
    EZH2["EZH2"]
    PRC2["PRC2 Complex"]
    TNF["TNF-alpha"]
    IL6["IL-6"]
    NFKB["NF-kappaB Pathway"]
    PI3K["PI3K/AKT"]
    MAPK["MAPK Pathway"]
    WNT["Wnt Pathway"]
    CTNNB1["beta-catenin"]
    INFLAMMATION["Neuroinflammation"]
    ALS["ALS"]
    MICRORNAS["miRNAs"]
    NEURODEGENERATION["Neurodegeneration"]

    EZH2 -->|"forms complex"| PRC2
    EED -->|"core component"| PRC2
    PRC2 -->|"H3K27me3"| NEURODEGENERATION

    TNF -->|"upregulates"| EED
    IL6 -->|"upregulates"| EED
    INFLAMMATION -->|"activates"| EED
    EED -->|"promotes"| INFLAMMATION

    EED -->|"regulates"| NFKB
    NFKB -->|"feedback"| EED
    PI3K -->|"modulates"| EED
    EED -->|"controls"| MAPK

    EED -->|"suppresses"| WNT
    WNT -->|"regulates"| CTNNB1
    EED -->|"targets"| CTNNB1

    EED -->|"activates"| ALS
    MICRORNAS -->|"therapeutic target"| EED

    EED -->|"drives"| NEURODEGENERATION

    style EED fill:#1a3a4a,stroke:#4fc3f7,color:#e0e0e0
    style MICRORNAS fill:#1b5e20,stroke:#4caf50
    style INFLAMMATION fill:#ef5350,stroke:#d32f2f
    style ALS fill:#7d4200,stroke:#f57c00
    style NEURODEGENERATION fill:#7d4200,stroke:#f57c00
    style PRC2 fill:#4a1a6b,stroke:#9c27b0
    style NFKB fill:#4a1a6b,stroke:#9c27b0

Outgoing (71)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.70
Als	activates	disease	0.65
Cancer	regulates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
ALZHEIMER	activates	gene	0.60
AMYLOID	activates	gene	0.60
Actin	activates	protein	0.60
Aβ	activates	protein	0.60
microglia	expressed_in	cell_type	0.60
GRN	associated_with	gene	0.60
INPP5D	associated_with	gene	0.60
LILRB2	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
PLCG2	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
AND	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
CR1	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
ABI3	associated_with	gene	0.60
CLU	associated_with	gene	0.60
phagocytosis	implicated_in	process	0.60
TAU PATHOLOGY	activates	gene	0.60
PTK2B	associated_with	gene	0.60
PHAGOCYTOSIS	associated_with	entity	0.60
MS4A6A	activates	gene	0.60
Phagocytosis	associated_with	pathway	0.60
Amyloid	activates	pathway	0.60
Complement	activates	pathway	0.60
MS4A6A	causes	gene	0.60
CTNNB1	regulates	gene	0.60
Microglia	associated_with	cell_type	0.60
Neuron	activates	cell_type	0.60
Microrna	regulates	pathway	0.60
ROS	activates	gene	0.60
BIN1	associated_with	gene	0.60
ADAM17	associated_with	gene	0.60
CTSH	associated_with	gene	0.60
APP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
ACE	associated_with	gene	0.60
ABCA1	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
Rb	associated_with	protein	0.60
SIGLEC11	implicated_in	gene	0.60
Wnt	regulates	pathway	0.60

Incoming (56)

Source	Relation	Type	Str
ALZHEIMER DISEASE	associated_with	gene	0.80
AND	associated_with	gene	0.60
COMPLEMENT	activates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
TNF	regulates	gene	0.60
PI3K	regulates	gene	0.60
EZH2	interacts_with	gene	0.60
BCL2	regulates	gene	0.60
GSK3B	regulates	gene	0.60
AKT	regulates	gene	0.60
LRP1	activates	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
NF-KB	regulates	gene	0.60
IL-6	regulates	gene	0.60
INFLAMMATION	activates	gene	0.60
TNF-Α	regulates	gene	0.60
GENES	interacts_with	gene	0.60
CANCER	regulates	gene	0.60
MICRORNAS	regulates	gene	0.60
ACE	associated_with	gene	0.60
ABCA1	associated_with	gene	0.60
ABI3	associated_with	gene	0.60
ADAM17	associated_with	gene	0.60
APOE	associated_with	gene	0.60
APP	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
CD33	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CR1	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
CTSH	associated_with	gene	0.60
PTK2B	associated_with	gene	0.60
LILRB2	associated_with	gene	0.60
PLCG2	associated_with	gene	0.60
GRN	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
INPP5D	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
TAU	activates	gene	0.60
AMYLOID	activates	gene	0.50
ALZHEIMER	activates	gene	0.50
CLU	co_discussed	gene	0.50
CR1	co_discussed	protein	0.50

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.863	Alzheimer's disease	Circuit-level neural dynamics in neurode
miR-155/Interferon-gamma Feedback Loop as a Reversible Molec	0.843	neurodegeneration	How do different microglial subtypes (DA
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.797	Alzheimer's disease	Circuit-level neural dynamics in neurode
H3: G3BP1 as Nucleation Hub for TDP-43/FUS Seeding	0.743	neurodegeneration	How do pathological stress granules tran
Tau missorting transitions into an autonomous tau-seeding st	0.740	neurodegeneration	Does tau dendritic missorting persist in

Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-002	0.733	molecular neurobiology	View
Cross-Seeding Prevention Strategy	0.689	neurodegeneration	RNA binding protein dysregulation across
TREM2 R47H variant synergizes with APOE4 to collapse microgl	0.670	neuroscience	APOE4-driven lipid metabolism dysregulat
Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro	0.642	neurodegeneration	What are the mechanisms by which gut mic
Seed match plus local RNA structure jointly determine lncRNA	0.640	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
H7: mTOR Hyperactivity Blocks Autophagy, Permitting Tau Seed	0.640	neurodegeneration	Entorhinal cortex layer II vulnerability
Autophagic Flux Enhancement Synergizes With Chaperones to Cl	0.640	protein folding	Can chaperone enhancement approaches ove
C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward	0.633	neuroinflammation	What molecular mechanisms determine whet
CX3CR1 Agonism Enhances Microglial Phagocytosis of Extracell	0.630	neurodegeneration	Investigate prion-like spreading of tau
Chaperone-Degradation Coupling Prevents Aggregate Persistenc	0.620	protein folding	Can chaperone enhancement approaches ove
Tau Cross-Seeding and Interaction	0.610	neurodegeneration	What mechanisms underlie TDP-43's contri
STING Antagonism Prevents Acute-to-Chronic Neuroinflammation	0.601	neuroinflammation	What molecular mechanisms drive the tran
A post-trigger CDK5-dominant kinase feedback loop maintains	0.590	neurodegeneration	Does tau dendritic missorting persist in
Peri-plaque tau seeding restraint via TREM2-competent microg	0.590	neurodegeneration	Does the cancer-cystatin-C-TREM2 pathway
Autophagy-Epigenetic Feedback Loop Creates a Compounding Bio	0.583	-	Epigenetic clocks as biomarkers for Alzh
APOE4 drives astrocyte metabolic reprogramming toward glycol	0.580	neuroscience	APOE4-driven lipid metabolism dysregulat
NAD+/SARM1 Axis Provides Metabolic Feedback Coupling Mitopha	0.578	neurodegeneration	How do different organelle-specific auto
Closed-loop transcranial focused ultrasound with real-time g	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time closed-loop transcranial focused ultrasound target	0.559	Alzheimer's disease	Circuit-level neural dynamics in neurode
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor	0.544	neurodegeneration	Protein aggregation cross-seeding across
Transient Chaperone Priming Prior to Seed Inoculation Preven	0.540	protein folding	Can chaperone enhancement approaches ove
TREM2-dependent microglial phagocytosis of tau seeds	0.530	neurodegeneration	Does the cancer-cystatin-C-TREM2 pathway
Soluble GAG-Mimetic Peptides Compete with HSPG for Tau Seed	0.510	neurodegeneration	Investigate prion-like spreading of tau
Neuronal Hypersensitivity to Feedback Inhibition by p62/Sequ	0.495	neurodegeneration	What mechanisms underlie neuronal resist
G3BP1-TDP-43 Cross-Seeding Drives Co-Aggregation That Prion-	0.490	neurodegeneration	How do disease-associated mutations in G

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Epigenetic clocks association with brain aging patterns in older women	exploratory	cognitive impairment and demen	0.900	0.00	human patients	proposed	N/A
TDP-43 mutant mouse model cGAS/STING pathway analysis	validation	amyotrophic lateral sclerosis	0.900	0.00	TDP-43 mutant mice	proposed	N/A
TDP-43 mitochondrial invasion and DNA release via mPTP	exploratory	amyotrophic lateral sclerosis	0.900	0.00	cultured cells	proposed	N/A
TDP-43 mitochondrial invasion and mtDNA release in iPSC motor neurons	exploratory	Amyotrophic Lateral Sclerosis	0.900	0.00	iPSC-derived motor neurons	proposed	N/A
cGAS/STING pathway validation in TDP-43 mutant mice	validation	Amyotrophic Lateral Sclerosis	0.850	0.00	TDP-43 mutant mice	proposed	N/A
cGAMP biomarker analysis in ALS patient spinal cord samples	exploratory	Amyotrophic Lateral Sclerosis	0.800	0.00	Human ALS patient spinal cord	proposed	N/A
TDP-43 pathology prevalence and distribution in AD cases	exploratory	Alzheimer's disease	0.800	0.00	human postmortem brain tissue	proposed	N/A
Cognitive impact of TDP-43 pathology in AD patients	clinical	Alzheimer's disease	0.700	0.00	human patients	proposed	N/A
Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
s:** - Single-cell RNA-seq to measure editing efficiency across differ	falsification	ALS	0.400	0.50	cell_line	proposed	$150,000
Alpha-Synuclein SAA Kinetics Study — Biological Staging Backbone for P	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020]	Chua JP, De Calbiac H, Kabashi E, Barmad	Autophagy	2022	2
TDP-43 Pathology in Alzheimer's Disease. [PMID:34930382]	Meneses A, Koga S, O'Leary J, Dickson DW	Mol Neurodegener	2021	2
Protein transmission in neurodegenerative disease. [PMID:32203399]	Peng C, Trojanowski JQ, Lee VM	Nat Rev Neurol	2020	2
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745]	Yu CH, Davidson S, Harapas CR, Hilton JB	Cell	2020	2
N protein of PEDV plays chess game with host proteins by selective autophagy. [PMID:36861818]	Zhai X, Kong N, Zhang Y, Song Y, Qin W,	Autophagy	2023	1
Role of Alpha-Synuclein in Frontotemporal Dementia: Narrative Review. [PMID:41827903]	Bougea A	Cells	2026	0
Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls [PMID:40899010]	Albrechtsen HM, Saritas G, Winge SB, Mai	J Clin Endocrinol Metab	2026	0
Epigenetics in chronic rhinosinusitis. [PMID:41442742]	Kumar N, Brar T, Lal D	Curr Opin Otolaryngol Head Nec	2026	0
Extracellular vesicles in type 2 diabetes exhibit elevated miR-155 cargo and Ann [PMID:41786286]	Jackson G, Islam H, de Souza Teixeira AA	Life Sci	2026	0
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207]	Mishra R, Gupta JK	Curr Alzheimer Res	2026	0
Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013]	Gu X, Sun F, Li Y, Yang S, Li Y	Int J Biol Macromol	2026	0
Extracellular Vesicles in Obesity: From Pathophysiological Mediators to Therapeu [PMID:41977323]	Pavlović N, Todorović P, Maglica M, Kopi	Int J Mol Sci	2026	0
The Genetics of TDP-43 Type C Neurodegeneration: A Whole-Genome Sequencing Study [PMID:41883703]	Nassan M, Ayala I, Sloan J, Bonfitto A,	Neurology. Genetics	2026	0
Computational examination of magainin-I-KL mediated disruption of E. coli biofil [PMID:41724836]	Vinutha AS, Akshay S, Sree Agash SG, Cha	Archives of microbiology	2026	0
Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progressi [PMID:41540015]	Ni N, Wang M, Yuan Z, Zhang L, Cai J, Du	International journal of oral	2026	0
The cytoplasmic protein YedX is a potent inhibitor of CsgA amyloid assembly in E [PMID:41581877]	Gurnani B, Jain N	The Journal of biological chem	2026	0
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207]	Mishra R, Gupta JK	Current Alzheimer research	2026	0
Biofluid biomarkers in Alzheimer's disease and other neurodegenerative dementias [PMID:41639575]	Zetterberg H, Bendlin BB	Nature	2026	0
Correction: Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibi [PMID:41775718]	Ni Nan; Wang Moxu; Yuan Zhiran; Zhang Le	International journal of oral	2026	0
Biofilm-Associated Amyloid Proteins Linked with the Progression of Neurodegenera [PMID:40141340]	Singh AA, Khan F, Song M	International journal of molec	2025	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EED in their description or question text

EED

Understanding Entity Pages

Summary

Wiki Pages (1)

EED

Pathway Diagram

Outgoing (71)

Incoming (56)

Targeting Hypotheses (30)

Mentioning Analyses (0)

Experiments (11)

Related Papers (20)

Debates (0)

Related Research

Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-0021/miR-6361 Binding S

Cross-Seeding Prevention Strategy

TREM2 R47H variant synergizes with APOE4 to collapse microglial lipid clearance

Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cross-Seeding

Seed match plus local RNA structure jointly determine lncRNA-0021 binding to mmu

H7: mTOR Hyperactivity Blocks Autophagy, Permitting Tau Seeding

Autophagic Flux Enhancement Synergizes With Chaperones to Clear High-Molecular-W

C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward Neurotoxic Loop

CX3CR1 Agonism Enhances Microglial Phagocytosis of Extracellular Tau Seeds, Prev

Chaperone-Degradation Coupling Prevents Aggregate Persistence by Shunting Seeds

Tau Cross-Seeding and Interaction

STING Antagonism Prevents Acute-to-Chronic Neuroinflammation Transition via Inte

A post-trigger CDK5-dominant kinase feedback loop maintains dendritic phospho-ta

Peri-plaque tau seeding restraint via TREM2-competent microglia

Autophagy-Epigenetic Feedback Loop Creates a Compounding Biomarker Signal — Auto