gene

NME8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NME8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

74Connections

0Hypotheses

0Analyses

40Outgoing

34Incoming

0Experiments

0Debates

Summary

NME8 Gene

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🧬 Gene Info

Gene Symbol	NME8
Protein Type	Kinase
Function	encodes a protein with nucleoside diphosphate kinase (NDPK) activity and a thioredoxin domain
Primary Expression	the retina and olfactory bulb, consistent with its role in ciliary function
UniProt ID	Q9NPJ3
Ensembl ID	ENSG00000186919
GeneCards	NME8
Human Protein Atlas	NME8
Associated Diseases	Als, Alzheimer, Ms
Interactions	ABCA7, AND, APOE, BIN1, CASS4, CD2AP
KG Connections	74 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: NME8 — AlphaFold Q9NPJ3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NME8/NDPK8 Protein

protein · 884 words

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NME8 Gene

gene · 621 words

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Pathway Diagram

graph TD
    NME8["NME8"]
    Ms{"Ms"}
    NME8 -->|"associated_with"| Ms
    Als{"Als"}
    NME8 -->|"associated_with"| Als
    Alzheimer{"Alzheimer"}
    NME8 -->|"associated_with"| Alzheimer
    ALZHEIMER["ALZHEIMER"]
    NME8 -->|"associated_with"| ALZHEIMER
    BIN1["BIN1"]
    NME8 -->|"associated_with"| BIN1
    CD2AP["CD2AP"]
    NME8 -->|"associated_with"| CD2AP
    INPP5D["INPP5D"]
    NME8 -->|"associated_with"| INPP5D
    EPHA1["EPHA1"]
    NME8 -->|"associated_with"| EPHA1
    CLU["CLU"]
    NME8 -->|"associated_with"| CLU
    CELF1["CELF1"]
    NME8 -->|"associated_with"| CELF1
    AND["AND"]
    NME8 -->|"associated_with"| AND
    GENES["GENES"]
    NME8 -->|"associated_with"| GENES
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    NME8 -->|"associated_with"| ALZHEIMER_S_DISEASE
    MEF2C["MEF2C"]
    NME8 -->|"associated_with"| MEF2C
    PTK2B["PTK2B"]
    NME8 -->|"associated_with"| PTK2B

Outgoing (40)

Target	Relation	Type	Str
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
HLA	associated_with	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
MIRNAS	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
AND	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
Amyloid	associated_with	pathway	0.60
App	associated_with	protein	0.60
CR1	interacts_with	gene	0.60
RIN3	interacts_with	gene	0.60
SLC24A4	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
BIN1	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
INPP5D	associated_with	gene	0.60
EPHA1	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CELF1	associated_with	gene	0.60
MEF2C	associated_with	gene	0.60
PTK2B	associated_with	gene	0.60
FERMT2	associated_with	gene	0.60
RIN3	associated_with	gene	0.60
ZCWPW1	associated_with	gene	0.60
PTK2B	interacts_with	gene	0.60
ZCWPW1	interacts_with	gene	0.60
ABCA7	interacts_with	gene	0.60
GAB2	interacts_with	gene	0.60
MS4A4E	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
TOMM40	interacts_with	gene	0.60
MS4A6A	interacts_with	gene	0.60
PICALM	interacts_with	gene	0.60
PTK2B	expressed_in	gene	0.60
TREM2	expressed_in	gene	0.60

Incoming (34)

Source	Relation	Type	Str
proteins-nme8-protein	describes	wiki_page	1.00
HLA	interacts_with	gene	0.60
PTK2B	interacts_with	gene	0.60
CD33	expressed_in	gene	0.60
ALZHEIMER	associated_with	gene	0.60
MS4A	interacts_with	gene	0.60
PLD3	associated_with	gene	0.60
ABCA7	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
CR1	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
CASS4	associated_with	gene	0.60
CD33	associated_with	gene	0.60
ZCWPW1	interacts_with	gene	0.60
GAB2	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
MS4A6A	interacts_with	gene	0.60
ABCA7	interacts_with	gene	0.60
PICALM	interacts_with	gene	0.60
MS4A4E	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
BIN1	interacts_with	gene	0.60
CD2AP	interacts_with	gene	0.60
TOMM40	interacts_with	gene	0.60
CASS4	interacts_with	gene	0.60
CD33	interacts_with	gene	0.60
CELF1	interacts_with	gene	0.60
EPHA1	interacts_with	gene	0.60
FERMT2	interacts_with	gene	0.60
INPP5D	interacts_with	gene	0.60
MEF2C	interacts_with	gene	0.60
MIRNAS	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NME8 in their description or question text

No additional research found