concept

ABL2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

0Analyses

43Outgoing

17Incoming

0Experiments

0Debates

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💡 Concept Info

Name	ABL2
Key Genes/Proteins	ABL1, App, CRLF2, CSF1R, Cytokine, EPOR
Related Diseases	Als, ALS

Pathway Diagram

graph TD
    ABL2["ABL2"]
    ABL2 -->|"activates"| Leukemia["Leukemia"]
    ABL2 -->|"activates"| Als["Als"]
    ABL2 -->|"activates"| ALS["ALS"]
    ABL2 -->|"activates"| STAT5["STAT5"]
    ABL2 -->|"contributes to"| NTRK3["NTRK3"]
    ABL2 -->|"contributes to"| PTK2B["PTK2B"]
    ABL2 -->|"expressed in"| ETV6["ETV6"]
    ABL2 -->|"activates"| ABL1["ABL1"]
    dasatinib["dasatinib"] -->|"inhibits"| ABL2
    ABL1 -->|"activates"| ABL2
    CSF1R["CSF1R"] -->|"activates"| ABL2
    EPOR["EPOR"] -->|"contributes to"| ABL2
    TSLP["TSLP"] -->|"contributes to"| ABL2
    GENES["GENES"] -->|"activates"| ABL2
    JAK2["JAK2"] -->|"activates"| ABL2
    NTRK3 -->|"contributes to"| ABL2

Outgoing (43)

Target	Relation	Type	Str
R-HSA-9706369	member_of	pathway	1.00
R-HSA-428890	member_of	pathway	1.00
R-HSA-9013149	member_of	pathway	1.00
R-HSA-9013423	member_of	pathway	1.00
ALS	activates	disease	0.65
Als	activates	disease	0.65
Leukemia	activates	disease	0.65
STAT5	activates	protein	0.64
CRLF2	contributes_to	gene	0.60
B Cell	activates	cell_type	0.60
Cytokine	activates	protein	0.60
CRLF2	activates	gene	0.60
EPOR	activates	gene	0.60
FLT3	activates	gene	0.60
IL7R	activates	gene	0.60
NTRK3	activates	gene	0.60
PTK2B	activates	gene	0.60
TSLP	activates	gene	0.60
TYK2	activates	gene	0.60
CSF1R	expressed_in	gene	0.60
EPOR	expressed_in	gene	0.60
JAK2	expressed_in	gene	0.60
NTRK3	expressed_in	gene	0.60
PDGFRB	expressed_in	gene	0.60
NTRK3	contributes_to	gene	0.60
PTK2B	contributes_to	gene	0.60
ETV6	expressed_in	gene	0.60
ABL1	activates	gene	0.60
PDGFRB	activates	gene	0.60
GENES	activates	gene	0.60
JAK2	activates	gene	0.60
EPOR	contributes_to	gene	0.60
CSF1R	activates	gene	0.60
TYK2	contributes_to	gene	0.60
IL7R	contributes_to	gene	0.60
TSLP	contributes_to	gene	0.60
FLT3	contributes_to	gene	0.60
Raf	activates	protein	0.60
Rb	activates	protein	0.60
Pdgf	activates	protein	0.60
Fus	expressed_in	protein	0.60
App	activates	protein	0.60
B Cell	expressed_in	cell_type	0.55

Incoming (17)

Source	Relation	Type	Str
dasatinib	inhibits	drug	0.72
CSF1R	activates	gene	0.60
EPOR	contributes_to	gene	0.60
TSLP	contributes_to	gene	0.60
GENES	activates	gene	0.60
JAK2	activates	gene	0.60
NTRK3	contributes_to	gene	0.60
CRLF2	contributes_to	gene	0.60
FLT3	contributes_to	gene	0.60
ABL1	expressed_in	gene	0.60
dasatinib	targets	drug	0.60
ABL1	activates	gene	0.60
TYK2	contributes_to	gene	0.60
IL7R	contributes_to	gene	0.60
ETV6	expressed_in	gene	0.60
PDGFRB	activates	gene	0.60
PTK2B	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ABL2 in their description or question text

No additional research found