gene

AVP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AVP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

128Connections

0Hypotheses

0Analyses

50Outgoing

43Incoming

0Experiments

0Debates

Summary

AVP is a gene implicated in neurodegeneration research. Key relationships include: expressed in, activates, regulates. Associated with ALS, Als, Cardiovascular. Connected to 43 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	AVP
Chromosome	20p13
Function	The AVP gene encodes preprovasopressin, which is processed to mature AVP (arginine vasopressin) along with neurophysin I and a glycopeptide.
Primary Expression	brain regions involved in social and homeostatic functions:
Pathways	Chaperone
Ensembl ID	ENSG00000101290
GeneCards	AVP
Human Protein Atlas	AVP
Associated Diseases	Alopecia Areata, Alzheimer, Cancer, Cardiovascular, Diabetes, Hypertension
Interactions	AND, CLOCK, CLOCK GENE, CRH, Cytokine, CYTOKINES
KG Connections	128 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    AVP["AVP"]
    Tumor{"Tumor"}
    AVP -->|"expressed in"| Tumor
    Als{"Als"}
    AVP -->|"activates"| Als
    Diabetes{"Diabetes"}
    AVP -->|"activates"| Diabetes
    Ms{"Ms"}
    AVP -->|"contributes to"| Ms
    Heart_Failure{"Heart Failure"}
    AVP -->|"activates"| Heart_Failure
    AVP -->|"regulates"| Diabetes
    AVP -->|"regulates"| Ms
    Cardiovascular{"Cardiovascular"}
    AVP -->|"regulates"| Cardiovascular
    ALS{"ALS"}
    AVP -->|"activates"| ALS
    POMC["POMC"]
    AVP -->|"expressed in"| POMC
    CRHR1["CRHR1"]
    AVP -->|"expressed in"| CRHR1
    NR3C1["NR3C1"]
    AVP -->|"expressed in"| NR3C1
    CRH["CRH"]
    CRH -->|"expressed in"| AVP
    AQP4["AQP4"]
    AQP4 -->|"expressed in"| AVP
    MICROTUBULES["MICROTUBULES"]
    MICROTUBULES -->|"regulates"| AVP
    POMC -->|"expressed in"| AVP
    CRHR1 -->|"expressed in"| AVP
    AND["AND"]
    AND -->|"expressed in"| AVP
    TNF["TNF"]
    TNF -->|"expressed in"| AVP
    ESR1["ESR1"]
    ESR1 -->|"expressed in"| AVP
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"activates"| AVP
    JUN["JUN"]
    JUN -->|"activates"| AVP
    ESR2["ESR2"]
    ESR2 -->|"expressed in"| AVP
    NR3C1 -->|"expressed in"| AVP
    style AVP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (85)

Target	Relation	Type	Str
Hypothalamic-Pituitary-Adrenal Axis	component_of	pathway	0.90
ACTH	associated_with	protein	0.90
Alopecia Areata	upregulates	disease	0.85
Alopecia Areata	associated_with	disease	0.85
Suprachiasmatic Nucleus	expressed_in	cell_type	0.80
Suicide Risk	risk_factor_for	phenotype	0.75
CRH	interacts_with	gene	0.70
Ischemia	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Diabetes	associated_with	disease	0.65
Als	activates	disease	0.65
Ptsd	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Diabetes	activates	disease	0.65
Ms	contributes_to	disease	0.65
Alzheimer	expressed_in	disease	0.65
Depression	expressed_in	disease	0.65
Diabetes	regulates	disease	0.65
Heart Failure	activates	disease	0.65
Ms	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
ALS	activates	disease	0.65
Diabetes	causes	disease	0.65
Hypertension	associated_with	disease	0.65
Infection	activates	disease	0.65
Cardiovascular	implicated_in	disease	0.65
Heart Failure	biomarker_for	disease	0.65
Stroke	biomarker_for	disease	0.65
Myocardial Infarction	biomarker_for	disease	0.65
Ms	expressed_in	disease	0.65
Ataxia	expressed_in	disease	0.65
Circadian Rhythm	expressed_in	pathway	0.60
IL12	expressed_in	gene	0.60
NR3C2	expressed_in	gene	0.60
POMC	expressed_in	gene	0.60
CRHR1	expressed_in	gene	0.60
NR3C1	expressed_in	gene	0.60
JUN	activates	gene	0.60
ESR1	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
ESR2	expressed_in	gene	0.60
CRH	expressed_in	gene	0.60
DEPRESSION	expressed_in	gene	0.60
FKBP5	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60
POMC	associated_with	gene	0.60
CLOCK	inhibits	gene	0.60
Rb	activates	protein	0.60
Rb	inhibits	protein	0.60

Incoming (43)

Source	Relation	Type	Str
NEUROTOXICITY	activates	gene	0.60
CIRCADIAN RHYTHM	expressed_in	gene	0.60
AND	inhibits	gene	0.60
CLOCK GENE	inhibits	gene	0.60
IL12	expressed_in	gene	0.60
NR3C2	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
DEPRESSION	expressed_in	gene	0.60
POMC	expressed_in	gene	0.60
CRHR1	expressed_in	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
REST	expressed_in	gene	0.60
ATXN3	expressed_in	gene	0.60
BMAL1	expressed_in	gene	0.60
PER2	expressed_in	gene	0.60
CLOCK	inhibits	gene	0.60
MICROTUBULES	regulates	gene	0.60
CYTOKINES	activates	gene	0.60
RNA	regulates	gene	0.60
AND	biomarker_for	gene	0.60
GENES	associated_with	gene	0.60
DNA	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
AND	associated_with	gene	0.60
AQP4	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
ESR1	expressed_in	gene	0.60
JUN	activates	gene	0.60
ESR2	expressed_in	gene	0.60
NR3C1	expressed_in	gene	0.60
STROKE	biomarker_for	gene	0.60
GENES	causes	gene	0.60
CRH	associated_with	gene	0.60
CRH	expressed_in	gene	0.60
CRH	biomarker_for	gene	0.60
NR3C1	biomarker_for	gene	0.60
TAC1	biomarker_for	gene	0.60
FOXP1	biomarker_for	gene	0.60
POMC	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AVP in their description or question text

No additional research found

AVP