cell 1,141 words KG: ent-gene-f71a9e3c
Contents

Hypothalamic Arcuate POMC Neurons

🔬 Protein Info
Gene Symbolent-gene-f71a9e3c
Morphologypro-opiomelanocortin neuron (source: Cell Ontology)
PositionAdjacent to the floor of the third ventricle
BoundariesDorsal to the median eminence, ventral to the ventromedial hypothalamus
Blood-brain barrierPartially circumventricular organ with leaky capillaries
Access to circulating signalsPeripheral hormones (leptin, ghrelin, insulin) can access ARC neurons
POMC geneProopiomelanocortin precursor protein
Insulin receptorsMetabolic sensing
Leptin receptors (LepRb)Leptin sensitivity
Serotonin receptors (5-HT2C)Serotonin modulation
Melanocortin-4 receptors (MC4R)Autoreceptor function
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (7)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
APOE-Dependent Autophagy Restoration
Score: 0.86
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
...
Score: 0.68

Related Analyses (13)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

Knowledge Graph (2 edges)

ent-gene-f71a9e3c data_in benchmark_ot_ad_answer_key:POMC
benchmark_ot_ad_answer_key:POMC data_in ent-gene-f71a9e3c

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