pathway

Dna Methylation

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Dna Methylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

930Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Dna Methylation is a biological pathway involved in neurodegeneration research. Key relationships include: associated with, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 496 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Dna Methylation
Key Genes/Proteins	ABCB1, ABCG1, ACE, Actin, ADRA1A, ADRA1B
Related Diseases	aging, Aging, Als
Related Pathways	Akt

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DNA Methylation

entity · 1249 words

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Pathway Diagram

graph TD
    Dna_Methylation["Dna Methylation"] -->|"interacts"| Wnt["Wnt"]
    Dna_Methylation["Dna Methylation"] -->|"interacts"| Epigenetic["Epigenetic"]
    Dna_Methylation["Dna Methylation"] -->|"interacts"| Mtor["Mtor"]
    Dna_Methylation["Dna Methylation"] -->|"interacts"| Akt["Akt"]
    Dna_Methylation["Dna Methylation"] -->|"interacts"| Pi3K["Pi3K"]
    IDH1["IDH1"] -->|"therapeutic target"| Dna_Methylation["Dna Methylation"]
    VEGFA["VEGFA"] -->|"therapeutic target"| Dna_Methylation["Dna Methylation"]
    MDM4["MDM4"] -->|"therapeutic target"| Dna_Methylation["Dna Methylation"]
    APOB["APOB"] -->|"therapeutic target"| Dna_Methylation["Dna Methylation"]
    style Dna_Methylation fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (141)

Target	Relation	Type	Str
Human Aging	biomarker_for	process	0.95
Neurological Disorders	involved_in	disease	0.95
Neurodegenerative Diseases	involved_in	disease	0.95
mammalian brain development	involved_in	process	0.95
learning and memory	regulates	phenotype	0.90
frontal cortex	expressed_in	brain_region	0.90
Therapy Resistance	contributes_to	phenotype	0.90
Progression Of Neurological Disorders	contributes_to	phenotype	0.90
Thyroid Cancer	involved_in	disease	0.90
BRAIN DEVELOPMENT	involved_in	entity	0.90
Mammalian Brain Development	mediates	process	0.90
PI3K/AKT/mTOR	regulates	pathway	0.90
Mitochondrial Dysfunction Gene Expression	regulates	process	0.90
Primary Open Angle Glaucoma	involved_in	disease	0.85
Post-Stroke Depression	involved_in	disease	0.85
synaptic plasticity	involved_in	process	0.85
CRHBP	regulates	gene	0.85
Clear-Cell Renal Cell Carcinoma	biomarker_for	disease	0.85
CRHR1	regulates	gene	0.85
CRH	regulates	gene	0.85
CORTEX	expressed_in	entity	0.85
Clear-Cell Renal Cell Carcinoma	involved_in	disease	0.85
Gene Expression	regulates	process	0.85
Gene expression	regulates	biological_process	0.80
neurological disorders	associated_with	disease	0.80
Hypersexual Disorder	biomarker_for	disease	0.80
HPA axis	regulates	pathway	0.80
Central Precocious Puberty	mediates	disease	0.75
Disease Prevention	involved_in	process	0.75
Forensics	involved_in	process	0.70
gene transcription	regulates	process	0.70
Alzheimer's disease	associated_with	disease	0.70
Parkinson's Disease	regulates	disease	0.70
AGING	interacts_with	phenotype	0.65
P53	processes	gene	0.65
MTOR	processes	gene	0.65
PI3K	processes	gene	0.65
UBIQUITIN	activates	gene	0.65
KEAP1	processes	gene	0.65
NRF2	processes	gene	0.65
SYNAPTIC PLASTICITY	protects_against	phenotype	0.60
AUTOPHAGY	inhibits	phenotype	0.60
NEURONS	treats	cell_type	0.60
TUMOR	causes	disease	0.60
HTT	interacts_with	gene	0.60
P300	regulates	gene	0.60
STING	interacts_with	gene	0.60
TUMOR	expressed_in	disease	0.60
T CELL	regulates	cell_type	0.60
T CELLS	regulates	cell_type	0.60

Incoming (789)

Source	Relation	Type	Str
GENES	regulates	gene	1.00
GENES	associated_with	gene	1.00
Cancer	associated_with	disease	1.00
Cancer	expressed_in	disease	1.00
DNA	regulates	gene	1.00
DNA	associated_with	gene	1.00
Als	associated_with	disease	1.00
DNA	activates	gene	1.00
DNA	inhibits	gene	1.00
INFLAMMATION	regulates	gene	1.00
CANCER	regulates	gene	1.00
Als	regulates	disease	1.00
Cancer	regulates	disease	1.00
CANCER	associated_with	gene	1.00
Inflammation	regulates	disease	1.00
Als	therapeutic_target	disease	1.00
Als	treats	disease	1.00
CANCER	expressed_in	gene	1.00
APOPTOSIS	regulates	gene	1.00
Gut Microbiota	modulates	process	0.95
dCas9-Tet1	associated_with	protein	0.90
dCas9-Dnmt3a	associated_with	protein	0.90
Tumor	therapeutic_target	disease	0.90
DNA	implicated_in	gene	0.90
Aging	associated_with	disease	0.90
GENES	therapeutic_target	gene	0.90
DNA	expressed_in	gene	0.90
Als	expressed_in	disease	0.90
Tumor	regulates	disease	0.90
Cancer	therapeutic_target	disease	0.90
2-hydroxyglutarate	promotes	compound	0.85
PSME2	correlates_with	gene	0.85
PSME2	correlates_with	gene	0.80
HSV-gB	modulates	protein	0.80
DNA	causes	gene	0.80
INFLAMMATION	associated_with	gene	0.80
AUTOPHAGY	regulates	gene	0.80
AGING	associated_with	gene	0.80
Inflammation	associated_with	disease	0.80
CANCER	inhibits	gene	0.80
ALZHEIMER	associated_with	gene	0.80
OXIDATIVE STRESS	regulates	gene	0.80
OVERVIEW	treats	gene	0.80
MICRORNAS	regulates	gene	0.80
GENES	inhibits	gene	0.80
CANCER	therapeutic_target	gene	0.80
DNA	therapeutic_target	gene	0.80
GENES	expressed_in	gene	0.80
Tumor	associated_with	disease	0.80
Tumor	expressed_in	disease	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity