gene

NFM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections

0Hypotheses

0Analyses

27Outgoing

24Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	NFM
Full Name	Neurofilament Medium Chain
Chromosome	8p21.2
Protein Family	Intermediate filament family
Function	is a neuronal intermediate filament protein encoded by the NEFM gene on chromosome 8p21, adjacent to the NEFL gene.
Primary Expression	Axon, neuronal cytoplasm
Amino Acids	916 aa
Exons	10
Pathways	Alpha-Synuclein, Er Stress, Synaptic Plasticity
UniProt ID	P12036
NCBI Gene ID	4741
Ensembl ID	ENSG00000104722
GeneCards	NFM
Human Protein Atlas	NFM
Associated Diseases	Parkinson
Interactions	AIF1, AMPK, ARC, CAMKK2, COX4I1, GFAP
KG Connections	51 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NFM — AlphaFold P12036 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NFM — Neurofilament Medium Chain

gene · 2470 words

→

Neurofilament Medium (NFM) Protein

protein · 614 words

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Pathway Diagram

graph TD
    NFM["NFM"]
    Parkinson["Parkinson"]
    NFM -->|"regulates"| Parkinson
    DJ_1["DJ-1"]
    NFM -->|"regulates"| DJ_1
    LMX1B["LMX1B"]
    NFM -->|"regulates"| LMX1B
    NURR1["NURR1"]
    NFM -->|"regulates"| NURR1
    SNCA["SNCA"]
    NFM -->|"regulates"| SNCA
    PARKINSON["PARKINSON"]
    NFM -->|"regulates"| PARKINSON
    Er_Stress["Er Stress"]
    NFM -->|"regulates"| Er_Stress
    Synaptic_Plasticity["Synaptic Plasticity"]
    NFM -->|"regulates"| Synaptic_Plasticity
    Dopaminergic["Dopaminergic"]
    NFM -->|"regulates"| Dopaminergic
    HNRNPA1["HNRNPA1"]
    NFM -->|"associated with"| HNRNPA1
    PGC1ALPHA["PGC1ALPHA"]
    NFM -->|"regulates"| PGC1ALPHA
    PARK7["PARK7"]
    NFM -->|"regulates"| PARK7
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    NFM -->|"regulates"| PARKINSON_S_DISEASE
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    NFM -->|"regulates"| ALPHA_SYNUCLEIN
    Alpha_Synuclein["Alpha-Synuclein"]
    NFM -->|"regulates"| Alpha_Synuclein
    HNRNPA1["HNRNPA1"]
    HNRNPA1 -->|"associated with"| NFM
    PARK7["PARK7"]
    PARK7 -->|"regulates"| NFM
    PINK1["PINK1"]
    PINK1 -->|"regulates"| NFM
    LMX1B["LMX1B"]
    LMX1B -->|"regulates"| NFM
    PARKINSON["PARKINSON"]
    PARKINSON -->|"regulates"| NFM
    SNCA["SNCA"]
    SNCA -->|"regulates"| NFM
    SFPQ["SFPQ"]
    SFPQ -->|"regulates"| NFM
    DJ_1["DJ-1"]
    DJ_1 -->|"regulates"| NFM
    AND["AND"]
    AND -->|"associated with"| NFM
    neurodegeneration["neurodegeneration"]
    NFM -->|"implicated in"| neurodegeneration

Outgoing (27)

Target	Relation	Type	Str
Parkinson	regulates	disease	0.65
PINK1	regulates	gene	0.60
DJ-1	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
Er Stress	regulates	pathway	0.60
Synaptic Plasticity	regulates	pathway	0.60
Parkinson	associated_with	disease	0.60
Dopaminergic	regulates	cell_type	0.60
RNA	activates	gene	0.60
HNRNPA1	associated_with	gene	0.60
PGC1ALPHA	regulates	gene	0.60
PARK7	regulates	gene	0.60
NPY	activates	gene	0.60
POMC	activates	gene	0.60
PRKN	activates	gene	0.60
RBFOX3	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
ALPHA-SYNUCLEIN	regulates	gene	0.60
Alpha-Synuclein	regulates	pathway	0.60
App	regulates	protein	0.60
LMX1B	regulates	gene	0.60
NURR1	regulates	gene	0.60
SNCA	regulates	gene	0.60
NURR1	co_expressed_with	gene	0.50
PARK7	co_expressed_with	gene	0.50

Incoming (24)

Source	Relation	Type	Str
PGC1ALPHA	regulates	gene	0.60
NURR1	regulates	gene	0.60
NEFM	activates	gene	0.60
PARK7	regulates	gene	0.60
PINK1	regulates	gene	0.60
MAP1LC3B	activates	gene	0.60
HNRNPA1	associated_with	gene	0.60
AIF1	activates	gene	0.60
ARC	activates	gene	0.60
CAMKK2	activates	gene	0.60
COX4I1	activates	gene	0.60
GFAP	activates	gene	0.60
IBA1	activates	gene	0.60
LAMP2	activates	gene	0.60
PARKINSON	regulates	gene	0.60
DJ-1	regulates	gene	0.60
AND	associated_with	gene	0.60
AMPK	activates	gene	0.60
LC3B	activates	gene	0.60
LMX1B	regulates	gene	0.60
SNCA	regulates	gene	0.60
SFPQ	regulates	gene	0.60
HNRNPA1	co_expressed_with	gene	0.50
LMX1B	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NFM in their description or question text

No additional research found