gene

NEFM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEFM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections

0Hypotheses

0Analyses

30Outgoing

21Incoming

0Experiments

0Debates

Summary

Page for NEFM — Neurofilament Medium Chain

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🧬 Gene Info

Gene Symbol	NEFM
Full Name	Neurofilament Medium Chain
Chromosome	8q21.3
Function	The NEFM gene encodes the 102.5 kDa neurofilament medium polypeptide, which assembles with neurofilament light chain (NEFL) and heavy chain (NEFH) to form the neuronal intermediate filament cytoskelet
Primary Expression	Motor neurons, Sensory neurons, Spinal cord, Brainstem, Hippocampus, Cerebral cortex
Molecular Weight	102.5 kDa
UniProt ID	P12036
NCBI Gene ID	4741
Ensembl ID	ENSG00000104722
OMIM	162400
GeneCards	NEFM
Human Protein Atlas	NEFM
Interactions	AIF1, AMPK, ARC, CAMKK2, CNR1, COX4I1
KG Connections	51 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NEFM — AlphaFold P12036 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NEFM — Neurofilament Medium Chain

gene · 529 words

→

Neurofilament Medium Chain (NEFM) Protein

protein · 587 words

→

Pathway Diagram

graph TD
    NEFM["NEFM"]
    Alzheimer{"Alzheimer"}
    NEFM -->|"expressed_in"| Alzheimer
    CNR1(["CNR1"])
    NEFM -->|"regulates"| CNR1
    TAU(["TAU"])
    NEFM -->|"expressed_in"| TAU
    Amyloid["Amyloid"]
    NEFM -->|"expressed_in"| Amyloid
    ALZHEIMER(["ALZHEIMER"])
    NEFM -->|"expressed_in"| ALZHEIMER
    AMYLOID(["AMYLOID"])
    NEFM -->|"expressed_in"| AMYLOID
    NEFL(["NEFL"])
    NEFL -->|"regulates"| NEFM
    RGS4(["RGS4"])
    RGS4 -->|"regulates"| NEFM
    style NEFM fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (30)

Target	Relation	Type	Str
NEURODEGENERATIVE DISEASES	involved_in	disease	0.95
Amyotrophic Lateral Sclerosis	involved_in	disease	0.90
Alzheimer	expressed_in	disease	0.65
POMC	activates	gene	0.60
NFM	activates	gene	0.60
RBFOX3	activates	gene	0.60
PRKN	activates	gene	0.60
NPY	activates	gene	0.60
RNA	activates	gene	0.60
Amyloid	expressed_in	pathway	0.60
ALZHEIMER	expressed_in	gene	0.60
AMYLOID	expressed_in	gene	0.60
Amyloid Beta	expressed_in	protein	0.60
Tau Protein	expressed_in	protein	0.60
Collagen	regulates	protein	0.60
autophagy pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Ras	regulates	protein	0.60
App	expressed_in	protein	0.60
RAS	regulates	gene	0.60
TAU	expressed_in	gene	0.60
Transferrin	regulates	protein	0.60
Rb	regulates	protein	0.60
CNR1	regulates	gene	0.60
RGS4	regulates	gene	0.60
NEFL	regulates	gene	0.60
RGS4	interacts_with	gene	0.50
NEFL	interacts_with	gene	0.50
CNR1	interacts_with	protein	0.50
ERBB2	interacts_with	concept	0.50

Incoming (21)

Source	Relation	Type	Str
NEFL	regulates	gene	0.60
RGS4	regulates	gene	0.60
TAU	expressed_in	gene	0.60
CNR1	regulates	gene	0.60
AMPK	activates	gene	0.60
LC3B	activates	gene	0.60
AIF1	activates	gene	0.60
ARC	activates	gene	0.60
CAMKK2	activates	gene	0.60
COX4I1	activates	gene	0.60
GFAP	activates	gene	0.60
IBA1	activates	gene	0.60
LAMP2	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
GENES	regulates	gene	0.60
AND	regulates	gene	0.60
RAS	regulates	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
AMYLOID	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
ERBB2	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NEFM in their description or question text

No additional research found