Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PKD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PKD2 |
| Key Genes/Proteins | AND, App, BECN1, GENES, KCNK2, PIEZO |
| Related Diseases | Als |
| Related Pathways | autophagy pathway, oxidative stress response |
graph TD
PKD2["PKD2"]
PKD2 -->|"interacts"| BECN1["BECN1"]
PKD2 -->|"expressed in"| Periodontal_Ligament_Cell["Periodontal Ligament Cell"]
PKD2 -->|"expressed in"| Als["Als"]
PKD2 -->|"expressed in"| TRPA1["TRPA1"]
PKD2 -->|"expressed in"| T_Cell["T Cell"]
PKD2 -->|"interacts"| PLAT["PLAT"]
PKD2 -->|"interacts"| AND["AND"]
PKD2 -->|"expressed in"| TRPM8["TRPM8"]
PIEZO["PIEZO"] -->|"expressed in"| PKD2
PIEZO1["PIEZO1"] -->|"expressed in"| PKD2
TRPM8 -->|"expressed in"| PKD2
KCNK2["KCNK2"] -->|"expressed in"| PKD2
RNA["RNA"] -->|"expressed in"| PKD2
TRPA1 -->|"expressed in"| PKD2
PLAT -->|"interacts"| PKD2| Target | Relation | Type | Str |
|---|---|---|---|
| BECN1 | interacts_with | protein | 0.92 |
| Periodontal Ligament Cell | expressed_in | cell_type | 0.90 |
| Als | expressed_in | disease | 0.65 |
| TRPA1 | expressed_in | gene | 0.60 |
| T Cell | expressed_in | cell_type | 0.60 |
| PIEZO | expressed_in | gene | 0.60 |
| PIEZO1 | expressed_in | gene | 0.60 |
| PLAT | interacts_with | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| POMC | interacts_with | gene | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| TRPM8 | expressed_in | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| AND | interacts_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| App | interacts_with | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PKD2 in their description or question text
No additional research found